RGD Reference Report - Identification of SMEK2 as a candidate gene for regulation of responsiveness to dietary cholesterol in rats. - Rat Genome Database

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Identification of SMEK2 as a candidate gene for regulation of responsiveness to dietary cholesterol in rats.

Authors: Asahina, M  Haruyama, W  Ichida, Y  Sakamoto, M  Sato, M  Imaizumi, K 
Citation: Asahina M, etal., J Lipid Res. 2008 Aug 27.
RGD ID: 2300117
Pubmed: PMID:18753676   (View Abstract at PubMed)
DOI: DOI:10.1194/jlr.M800135-JLR200   (Journal Full-text)

We have previously mapped a diet-induced hypercholesterolemia locus (Dihc2) to chromosome 14 in the F2 generation crossed of high-responsive exogenous hypercholesterolemia rats and low-responsive BN rats. To identify a causal gene within this locus, we constructed interval-specific congenic lines (ISCLs) and carried out expression and sequencing analyses. Here we narrowed Dihc2 to region including 33 genes and predicted transcripts and identified RGD1309450_predicted, a homologous gene of SMEK2, as a strong candidate for responsiveness to dietary cholesterol. Our finding provides new insights into the pathway underlying the individual responsiveness to dietary cholesterol in vivo.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
ExHC/SeacRatHypercholesterolemia inducedIAGPcontrolled cholesterol content diet and controlled fat content diet RGD 
Scl59RatHypercholesterolemia  IAGP  RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Objects Annotated

QTLs
Scl59  (Serum cholesterol level QTL 59)

Objects referenced in this article
Gene PPP4R3B protein phosphatase 4 regulatory subunit 3B Homo sapiens
Gene Ppp4r3b protein phosphatase 4 regulatory subunit 3B Mus musculus
Marker D14Kyu7 D14Kyu7 Rattus norvegicus
Marker D14Kyu8 D14Kyu8 Rattus norvegicus
Strain BN/Seac null Rattus norvegicus
Gene Ppp4r3b protein phosphatase 4, regulatory subunit 3B Rattus norvegicus
QTL Scl45 Serum cholesterol level QTL 45 Rattus norvegicus

Additional Information