RGD Reference Report - CD34+ fibrocytes in chronic cystitis and noninvasive and invasive urothelial carcinomas of the urinary bladder. - Rat Genome Database

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CD34+ fibrocytes in chronic cystitis and noninvasive and invasive urothelial carcinomas of the urinary bladder.

Authors: Nimphius, W  Moll, R  Olbert, P  Ramaswamy, A  Barth, PJ 
Citation: Nimphius W, etal., Virchows Arch. 2007 Feb;450(2):179-85.
RGD ID: 2300021
Pubmed: PMID:17149610   (View Abstract at PubMed)
DOI: DOI:10.1007/s00428-006-0347-6   (Journal Full-text)

CD34+ fibrocytes are constitutive elements of the connective tissue where they play a role in matrix synthesis and tumor-associated stromal remodeling. Secreted protein, acidic, and rich in cysteine (SPARC) is a pivotal mediator of stromal remodeling precipitated by invasive carcinomas. The present study was undertaken to investigate CD34+ fibrocytes in the stroma of the tumor-free urinary bladder, chronic cystitis, and urothelial carcinomas together with stromal expression of alpha-smooth muscle actin (alpha-SMA), CD117, and SPARC. In tumor-free urinary bladder and chronic cystitis, CD34+ fibrocytes were found in the deep lamina propria and tunica muscularis, whereas the superficial lamina propria disclosed a CD34-negative and alpha-SMA-positive fibrocyte-like cell. Invasive urothelial carcinomas revealed a complete loss of CD34+ fibrocytes and concomitant appearance of alpha-SMA-reactive myofibroblasts which showed strong expression of SPARC. CD117 expression of tumor-free and tumor-associated stroma revealed no differences. We in this study for the first time describe CD34+ fibrocytes in the urinary bladder and an up-to-now unknown population of alpha-SMA-positive fibrocytes exclusively occurring in the superficial lamina propria. Stromal remodeling associated with invasive carcinomas in the urinary bladder is characterized by a loss of CD34+ fibrocytes paralleled by a gain of alpha-SMA-positive myofibroblasts and increased expression of SPARC.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
urinary bladder cancer  IEP 2300021 RGD 
urinary bladder cancer  ISOSPARC (Homo sapiens)2300021; 2300021 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Sparc  (secreted protein acidic and cysteine rich)

Genes (Mus musculus)
Sparc  (secreted acidic cysteine rich glycoprotein)

Genes (Homo sapiens)
SPARC  (secreted protein acidic and cysteine rich)


Additional Information