RGD Reference Report - Prognostic value of nm23 protein expression in renal cell carcinomas. - Rat Genome Database

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Prognostic value of nm23 protein expression in renal cell carcinomas.

Authors: Nakagawa, Y  Tsumatani, K  Kurumatani, N  Cho, M  Kitahori, Y  Konishi, N  Ozono, S  Okajima, E  Hirao, Y  Hiasa, Y 
Citation: Nakagawa Y, etal., Oncology. 1998 Jul-Aug;55(4):370-6.
RGD ID: 2299059
Pubmed: PMID:9663430   (View Abstract at PubMed)

In the present study, an analysis of whether expression of nm23-H1 and nm23-H2 proteins has prognostic significance was performed. A series of 95 renal cell carcinomas was analyzed for nuclear grade, tumor size (larger than 50 mm or not), staging in the Robson system and expression of nm23-H1 and nm23-H2, as well as patient survival. Immunohistochemical staining of nm23-H1 and nm23-H2 was found in 68.4 and 50.5% of the cases, respectively. Significant differences in nm23-H1, but not nm23-H2 expression were noted with regard to nuclear grade and tumor size. The patients with nm23-H1-expression-negative tumors sized < or = 50 mm had a significantly poorer prognosis than their positive counterparts. Multivariate analysis using the Cox proportional hazards regression model indicated that the staging in the Robson system and expression of nm23-H1 were significant and independent prognostic factors for survival. However, no significant correlation between the incidence of metastasis and expression of nm23-H1 or nm23-H2 was found. The results imply that reduced expression of nm23-H1 influences the prognosis of patients with renal cell carcinomas, but not the likelihood of metastasis. In small tumors sized < or = 50 mm, reduced expression of nm23-H1 protein was suggested to be an especially strong predictor of a poor prognosis.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
renal cell carcinoma disease_progressionIEP 2299059 RGD 
renal cell carcinoma disease_progressionISONME1 (Homo sapiens)2299059; 2299059 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Nme1  (NME/NM23 nucleoside diphosphate kinase 1)

Genes (Mus musculus)
Nme1  (NME/NM23 nucleoside diphosphate kinase 1)

Genes (Homo sapiens)
NME1  (NME/NM23 nucleoside diphosphate kinase 1)


Additional Information