RGD Reference Report - Expression of estrogen receptor coregulators in normal and malignant human endometrium. - Rat Genome Database

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Expression of estrogen receptor coregulators in normal and malignant human endometrium.

Authors: Kershah, SM  Desouki, MM  Koterba, KL  Rowan, BG 
Citation: Kershah SM, etal., Gynecol Oncol. 2004 Jan;92(1):304-13.
RGD ID: 2298984
Pubmed: PMID:14751175   (View Abstract at PubMed)

OBJECTIVES: To compare the expression of nuclear receptor coregulators in normal and malignant human endometrium and to identify any relationship to grade, stage, age, depth of myometrial invasion, estrogen receptor alpha (ERalpha), or progesterone receptor (PR) expression. METHODS: Gene expression of SRC-1, SRC-2, SRC-3, N-CoR, SMRT, ERalpha, and PR was measured in 26 samples of normal endometrium and 30 primary endometrial carcinomas using real-time RT-PCR. ERalpha protein expression of each tissue was also measured by Western blot. RESULTS:. All coregulators showed significantly increased mRNA expression in endometrial carcinoma as compared to normal endometrium. The mRNA expression of each coregulator showed a high correlation with ERalpha mRNA, PR mRNA, and with the other coregulators in both normal and malignant endometrium. In the normal endometrium, SRC-1 mRNA expression was positively correlated with ERalpha protein expression and SRC-3 mRNA expression was positively correlated with patient age. No relationship was found between coregulator mRNA expression and grade, stage, or depth of myometrial invasion.CONCLUSION: The nuclear receptor coregulators SRC-1, SRC-2, SRC-3, N-CoR, and SMRT were found to be up-regulated in malignant endometrium. Our findings suggest that these proteins may have a role in the development of endometrial carcinoma.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
endometrial carcinoma  IEP 2298984; 2298984mRNA:increased expression:endometriumRGD 
endometrial carcinoma  ISONCOA1 (Homo sapiens)2298984; 2298984mRNA:increased expression:endometriumRGD 
endometrial carcinoma  ISONCOR2 (Homo sapiens)2298984; 2298984mRNA:increased expression:endometriumRGD 

Objects Annotated

Genes (Rattus norvegicus)
Ncoa1  (nuclear receptor coactivator 1)
Ncor2  (nuclear receptor co-repressor 2)

Genes (Mus musculus)
Ncoa1  (nuclear receptor coactivator 1)
Ncor2  (nuclear receptor co-repressor 2)

Genes (Homo sapiens)
NCOA1  (nuclear receptor coactivator 1)
NCOR2  (nuclear receptor corepressor 2)


Additional Information