RGD Reference Report - Overexpression of anti-apoptotic gene BAG-1 in human cervical cancer. - Rat Genome Database

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Overexpression of anti-apoptotic gene BAG-1 in human cervical cancer.

Authors: Yang, X  Hao, Y  Ferenczy, A  Tang, SC  Pater, A 
Citation: Yang X, etal., Exp Cell Res. 1999 Feb 25;247(1):200-7.
RGD ID: 2293889
Pubmed: PMID:10047462   (View Abstract at PubMed)
DOI: DOI:10.1006/excr.1998.4349   (Journal Full-text)

Apoptosis is a programmed cell death process in which cells commit suicide under certain environmental conditions. Recent studies suggest that apoptosis is controlled by a variety of cellular genes, and dysregulation of these genes plays an important role in the pathogenesis of human diseases, including cancer. BAG-1 is a novel anti-apoptotic protein isolated by its interaction with another anti-apoptotic protein, Bcl-2. It binds to several hormone receptors and growth factor receptors and modulates their function in apoptosis. However, the role of BAG-1 in the oncogenesis of human cervical cancer has yet to be illustrated. In this study, we examined the expression of BAG-1 in cervical normal and carcinoma cultured cells and tissues. BAG-1 was overexpressed in human cervical carcinoma cell lines and tissues. Overexpression was regulated at the transcriptional level. The increased expression of BAG-1 was correlated with enhanced resistance of cervical carcinoma cells to apoptosis induced by a DNA-damaging reagent. In addition, overexpression of BAG-1 enhanced the resistance of cervical cells to apoptosis. This study provided the first evidence that BAG-1 is upregulated in human cervical cancer and may play an important role in apoptosis and human cervical carcinogenesis.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
cervix carcinoma  IEP 2293889protein:increased expression:uterine cervixRGD 
cervix carcinoma  ISOBAG1 (Homo sapiens)2293889; 2293889protein:increased expression:uterine cervixRGD 

Objects Annotated

Genes (Rattus norvegicus)
Bag1  (BAG cochaperone 1)

Genes (Mus musculus)
Bag1  (BCL2-associated athanogene 1)

Genes (Homo sapiens)
BAG1  (BAG cochaperone 1)


Additional Information