RGD Reference Report - Sex Differences in Circulating and Renal Angiotensins of Hypertensive mRen(2).Lewis but not Normotensive Lewis Rats. - Rat Genome Database

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Sex Differences in Circulating and Renal Angiotensins of Hypertensive mRen(2).Lewis but not Normotensive Lewis Rats.

Authors: Pendergrass, KD  Pirro, NT  Westwood, BM  Ferrario, CM  Brosnihan, KB  Chappell, MC 
Citation: Pendergrass KD, etal., Am J Physiol Heart Circ Physiol. 2008 May 2;.
RGD ID: 2293121
Pubmed: PMID:18456730   (View Abstract at PubMed)
PMCID: PMC2494740   (View Article at PubMed Central)
DOI: DOI:10.1152/ajpheart.01277.2007   (Journal Full-text)

Sex differences in blood pressure are evident in experimental models and human subjects, yet the mechanisms underlying this disparity remain equivocal. The current study sought to define the extent of male-female differences in the circulating and tissue renin-angiotensin aldosterone systems (RAAS) of the congenic mRen2.Lewis and the control Lewis rats. Male congenics exhibited higher systolic blood pressure than females [200 +/- 4 vs. 146 +/- 7 mmHg, p 0.05]. Plasma Ang II levels were 2-fold higher in male congenics [47 +/- 3 vs. 19 +/- 3 pM, p



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
LEW-Tg(Ren2)27/JmulRatproteinuria  IMP  RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
LEW-Tg(Ren2)27/JmulRatabnormal circulating C-reactive protein level  IMP compared to LEW/CrlRGD 
LEW-Tg(Ren2)27/JmulRatabnormal circulating C-reactive protein level sexual_dimorphismIMP compared to female LEW-TgRen227/JmulRGD 
LEW/CrlRatabnormal circulating C-reactive protein level sexual_dimorphismIAGP compared to female LEW/CrlRGD 
LEW/CrlRatdecreased body weight sexual_dimorphismIAGP compared to female LEW-TgRen227/JmulRGD 
LEW-Tg(Ren2)27/JmulRatdecreased circulating angiotensinogen level sexual_dimorphismIMP compared to female LEW/CrlRGD 
LEW/CrlRatdecreased heart left ventricle weight sexual_dimorphismIAGP compared to female LEW/CrlRGD 
LEW-Tg(Ren2)27/JmulRatdecreased kidney weight sexual_dimorphismIMP compared to female LEW/CrlRGD 
LEW/CrlRatdecreased kidney weight sexual_dimorphismIAGP compared to female LEW/CrlRGD 
LEW-Tg(Ren2)27/JmulRatdecreased renin activity sexual_dimorphismIMP compared to female LEW/CrlRGD 
LEW/CrlRatdecreased renin activity sexual_dimorphismIAGP compared to female LEW/Crl in kidneyRGD 
LEW-Tg(Ren2)27/JmulRatincreased angiotensin I-converting enzyme activity  IMP compared to male LEW/Crl and plasma and corticalRGD 
LEW-Tg(Ren2)27/JmulRatincreased angiotensin I-converting enzyme activity sexual_dimorphismIMP compared to female LEW-TgRen227/Jmul and plasma and corticalRGD 
LEW-Tg(Ren2)27/JmulRatincreased body weight sexual_dimorphismIMP compared to female LEW-TgRen227/JmulRGD 
LEW/CrlRatincreased body weight sexual_dimorphismIAGP compared to female LEW/CrlRGD 
LEW-Tg(Ren2)27/JmulRatincreased circulating renin level  IMP compared to LEW/Crl��RGD 
LEW-Tg(Ren2)27/JmulRatincreased circulating renin level sexual_dimorphismIMP compared to female LEW-TgRen227/JmulRGD 
LEW-Tg(Ren2)27/JmulRatincreased heart left ventricle weight sexual_dimorphismIMP compared to female LEW-TgRen227/JmulRGD 
LEW-Tg(Ren2)27/JmulRatincreased kidney weight sexual_dimorphismIMP compared to male LEW/Crl and compared to female LEW-TgRen227/JmulRGD 
LEW-Tg(Ren2)27/JmulRatincreased systemic arterial systolic blood pressure  IMP compared to LEW/Crl�RGD 
LEW-Tg(Ren2)27/JmulRatincreased systemic arterial systolic blood pressure sexual_dimorphismIMP compared to female LEW-TgRen227/JmulRGD 
LEW-Tg(Ren2)27/JmulRatincreased urine creatinine level  IMP  RGD 
LEW-Tg(Ren2)27/JmulRatincreased urine creatinine level sexual_dimorphismIMP compared to female LEW-TgRen227/JmulRGD 
LEW-Tg(Ren2)27/JmulRatincreased urine protein level sexual_dimorphismIMP compared to male LEW/Crl and compared to female LEW-TgRen227/JmulRGD 
Objects Annotated

Strains
LEW-Tg(Ren2)27/Jmul  (NA)
LEW/Crl  (Lewis)


Additional Information