RGD Reference Report - The correlations between HPV16 infection and expressions of c-erbB-2 and bcl-2 in breast carcinoma. - Rat Genome Database

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The correlations between HPV16 infection and expressions of c-erbB-2 and bcl-2 in breast carcinoma.

Authors: He, Q  Zhang, SQ  Chu, YL  Jia, XL  Wang, XL 
Citation: He Q, etal., Mol Biol Rep. 2008 Apr 22;.
RGD ID: 2292909
Pubmed: PMID:18427947   (View Abstract at PubMed)
DOI: DOI:10.1007/s11033-008-9249-9   (Journal Full-text)

Breast carcinoma (BC) is a prevalent malignant tumour occurring in women. Many studies have indicated the role of human papilloma virus type 16 (HPV16) in the pathogenesis of BC; however, the correlations of HPV16 infection with the clinicopathologic features of BC and the expressions of c-erbB-2 and bcl-2 have not yet been elucidated. In this study, HPV16 was detected by amplifying the HPV16 E6 gene by the polymerase chain reaction method, and the expressions of c-erbB-2 and bcl-2 in 40 BCs and 20 normal breast tissue samples, obtained from Shaanxi Province, were examined using the streptavidin-peroxidase method with monoclonal antibodies specific to c-erbB-2 and bcl-2. The infection rate of HPV16 E6 and the positive expression rate of c-erbB-2 were significantly higher in the BCs than in the normal tissues (HPV16 E6: 60% vs. 5%; c-erbB-2: 42.5% vs. 5%, P < 0.05). However, the positive expression rate of bcl-2 was significantly lower in the BCs than in the normal tissues (67.5% vs. 95%, P < 0.05). The infection rate of HPV16 did not correlate with any of the pathological features observed (P > 0.05). HPV16 infection correlated with bcl-2 expression (P = 0.015) but not with c-erbB-2 expression (P = 0.747) in the BCs. Interestingly, HPV16 infection correlated with bcl-2 expression in grade I BCs (P = 0.018) but not in grade II-III BCs (P = 0.633). Our data suggest that HPV16 infection is correlated with bcl-2 expression in BCs.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Breast Neoplasms  IEP 2292909associated with Papillomavirus Infections and protein:increased expression:breastRGD 
Breast Neoplasms  ISOBCL2 (Homo sapiens)2292909; 2292909associated with Papillomavirus Infections and protein:increased expression:breastRGD 
Breast Neoplasms  IEP 2292909protein:increased expression:breastRGD 
Breast Neoplasms  ISOERBB2 (Homo sapiens)2292909; 2292909protein:increased expression:breastRGD 

Objects Annotated

Genes (Rattus norvegicus)
Bcl2  (BCL2, apoptosis regulator)
Erbb2  (erb-b2 receptor tyrosine kinase 2)

Genes (Mus musculus)
Bcl2  (B cell leukemia/lymphoma 2)
Erbb2  (erb-b2 receptor tyrosine kinase 2)

Genes (Homo sapiens)
BCL2  (BCL2 apoptosis regulator)
ERBB2  (erb-b2 receptor tyrosine kinase 2)


Additional Information