RGD Reference Report - Submegabase resolution of epistatically interacting quantitative trait loci for blood pressure applicable for essential hypertension. - Rat Genome Database

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Submegabase resolution of epistatically interacting quantitative trait loci for blood pressure applicable for essential hypertension.

Authors: Chauvet, C  Charron, S  Menard, A  Xiao, C  Roy, J  Deng, AY 
Citation: Chauvet C, etal., J Hypertens. 2008 May;26(5):893-901.
RGD ID: 2292238
Pubmed: PMID:18398331   (View Abstract at PubMed)
DOI: DOI:10.1097/HJH.0b013e3282f85ded   (Journal Full-text)

OBJECTIVE: Although genetic mapping of quantitative trait loci for blood pressure to large chromosome segments is readily achievable, their final identification confronts formidable hurdles. Restriction of the genes lodging in one quantitative trait locus interval to experimental limitation can facilitate their positional cloning. We previously delineated several quantitative trait loci for blood pressure on chromosome 10 of Dahl salt-sensitive rats, but their chromosome delimitations were either large or not definitive. METHODS: In this study, we systematically and comprehensively constructed congenic strains with submegabase (Mb) genome resolution and analyzed their blood pressure by telemetry. RESULTS: Three quantitative trait loci have been conclusively delimited by three congenic strains, each independently lowering the blood pressure. Their intervals are demarcated by genomic regions between 350 and 910 kilobases (kb) in size. Two of the three quantitative trait loci share an epistatic relationship and are separated from one another by less than 170 kb. Two additional quantitative trait loci for blood pressure were also tentatively delineated and their intervals range from 520 kb to 1.75 Mb. Possible genes dwelling in each quantitative trait locus-interval number between 11 and 17. None of these genes is known to exert a functional impact on blood pressure. Work is underway to find candidate genes with mutations that could be responsible for the blood pressure effect. CONCLUSION: Novel diagnostic, prognostic, preventive and/or therapeutic targets for essential hypertension and hypertension-associated diseases are likely to emerge from the identification of these quantitative trait loci. Potential applications of these quantitative trait loci to humans are suggested from the positive results from several association studies, demonstrating the existence of quantitative trait loci in the broad homologous regions.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Hypotension  IAGP 2292238; 2292238; 2292238; 2292238; 2292238 RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype


Objects Annotated

QTLs
Bp308  (Blood pressure QTL 308)
Bp309  (Blood pressure QTL 309)
Bp310  (Blood pressure QTL 310)
Bp311  (Blood pressure QTL 311)
Bp312  (Blood pressure QTL 312)

Objects referenced in this article
QTL Bp279 Blood pressure QTL 279 Rattus norvegicus
QTL Bp280 Blood pressure QTL 280 Rattus norvegicus
QTL Bp281 Blood pressure QTL 281 Rattus norvegicus
QTL Bp282 Blood pressure QTL 282 Rattus norvegicus
Strain SS.LEW-(D10Chm128-D10Chm121)/Ayd null Rattus norvegicus
Strain SS.LEW-(D10Chm128-D10Chm169)/Ayd null Rattus norvegicus
Strain SS.LEW-(D10Chm224-D10Chm222)/Ayd null Rattus norvegicus
Strain SS.LEW-(D10Mco30-D10Got92)/Ayd null Rattus norvegicus
Strain SS.LEW-(D10Rat17-D10Mgh1)/Ayd null Rattus norvegicus
Strain SS.LEW-(D10Rat204-D10Rat9)/Ayd null Rattus norvegicus
Strain SS.LEW-(D10Rat24-Igfbp4)/Ayd null Rattus norvegicus
Strain SS.LEW-(D10Rat27-Igfbp4)/Ayd null Rattus norvegicus

Additional Information