RGD Reference Report - Stromal nitric oxide synthase (NOS) expression correlates with the grade of mammary phyllodes tumour. - Rat Genome Database

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Stromal nitric oxide synthase (NOS) expression correlates with the grade of mammary phyllodes tumour.

Authors: Tse, GM  Wong, FC  Tsang, AK  Lee, CS  Lui, PC  Lo, AW  Law, BK  Scolyer, RA  Karim, RZ  Putti, TC 
Citation: Tse GM, etal., J Clin Pathol. 2005 Jun;58(6):600-4.
RGD ID: 2292077
Pubmed: PMID:15917410   (View Abstract at PubMed)
PMCID: PMC1770683   (View Article at PubMed Central)
DOI: DOI:10.1136/jcp.2004.023028   (Journal Full-text)

BACKGROUND: Nitric oxide synthase (NOS), particularly endothelial and inducible forms (e/i-NOS), are expressed in various cancers, including breast cancer. In mammary fibroepithelial lesions, NOS expression in stromal cells has been reported to be lower in fibroadenomas than in phyllodes tumours. AIMS: To investigate NOS expression in phyllodes tumours of varying degrees of malignancy. METHODS: One hundred and sixty seven mammary phyllodes tumours (97 benign, 47 borderline malignant, and 23 frankly malignant) were evaluated for e-NOS and i-NOS expression by immunohistochemistry. Correlations with previously reported expression of stromal vascular growth factor (VEGF) and microvessel density were also performed. RESULTS: Stromal expression of e-NOS was absent, weak, moderate, and strong in 43%, 31%, 13%, and 13% of benign tumours; 17%, 26%, 13%, and 44% of borderline malignant tumours; and 17%, 35%, 13%, and 35% of frankly malignant tumours, respectively. Stromal expression of i-NOS was 77%, 18%, 4%, and 1% in benign tumours; 42%, 28%, 19%, and 11% in borderline malignant tumours; and 43%, 13%, 26%, and 18% in frankly malignant tumours, respectively. Stromal expression of both i-NOS and e-NOS was significantly different between the benign and malignant (borderline and frank) groups of phyllodes tumours (p < 0.0001). Furthermore, the expression of i-NOS correlated with stromal VEGF expression and microvessel density. The expression of NOS in the epithelial cells was strong, and showed no differences between the different groups of tumours. CONCLUSIONS: Higher stromal expression of NOS in phyllodes tumours is associated with malignancy, suggesting a possible role in malignant progression, particularly metastasising potential.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Phyllodes Tumor  IEP 2292077protein:increased expression:breastRGD 
Phyllodes Tumor  ISONOS3 (Homo sapiens)2292077; 2292077protein:increased expression:breastRGD 

Objects Annotated

Genes (Rattus norvegicus)
Nos3  (nitric oxide synthase 3)

Genes (Mus musculus)
Nos3  (nitric oxide synthase 3, endothelial cell)

Genes (Homo sapiens)
NOS3  (nitric oxide synthase 3)


Additional Information