RGD Reference Report - p73 is over-expressed in vulval cancer principally as the Delta 2 isoform. - Rat Genome Database

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p73 is over-expressed in vulval cancer principally as the Delta 2 isoform.

Authors: O'Nions, J  Brooks, LA  Sullivan, A  Bell, A  Dunne, B  Rozycka, M  Reddy, A  Tidy, JA  Evans, D  Farrell, PJ  Evans, A  Gasco, M  Gusterson, B  Crook, T 
Citation: O'Nions J, etal., Br J Cancer. 2001 Nov 16;85(10):1551-6.
RGD ID: 2290590
Pubmed: (View Article at PubMed) PMID:11720444
DOI: Full-text: DOI:10.1054/bjoc.2001.2138

p73 was studied in squamous cancers and precursor lesions of the vulva. Over-expression of p73 occurred commonly in both human papillomavirus (HPV)-positive and -negative squamous cell cancers (SCC) and high-grade premalignant lesions. Whereas expression in normal vulval epithelium was detected only in the basal and supra-basal layers, expression in neoplastic epithelium increased with grade of neoplasia, being maximal at both protein and RNA levels in SCC. p73 Delta 2 was the principal over-expressed isoform in the majority of cases of vulval SCC and often the sole form expressed in SCC. Over-expression of p73 was associated with expression of HPV-encoded E7 or with hypermethylation or mutation of p16(INK4a) in HPV-negative cases. There was a close correlation between expression of p73 and p14(ARF) in cancers with loss of p53 function. The frequent over-expression of p73 Delta 2 in neoplastic but not normal vulval epithelium, and its co-ordinate deregulation with other E2F-1 responsive genes suggests a role in the oncogenic process.

Annotation

Disease Annotations    
Vulvar Neoplasms  (IEP,ISO)

Objects Annotated

Genes (Rattus norvegicus)
Tp73  (tumor protein p73)

Genes (Mus musculus)
Trp73  (transformation related protein 73)

Genes (Homo sapiens)
TP73  (tumor protein p73)


Additional Information