RGD Reference Report - The GH1/IGF-1 axis polymorphisms and their impact on breast cancer development. - Rat Genome Database

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The GH1/IGF-1 axis polymorphisms and their impact on breast cancer development.

Authors: Wagner, K  Hemminki, K  Forsti, A 
Citation: Wagner K, etal., Breast Cancer Res Treat. 2007 Sep;104(3):233-48. Epub 2006 Nov 2.
RGD ID: 2290013
Pubmed: PMID:17082888   (View Abstract at PubMed)
DOI: DOI:10.1007/s10549-006-9411-9   (Journal Full-text)

The growth hormone 1/insulin-like growth factor-1 (GH1/IGF-1) axis plays an essential role in the development of the breast by regulating cell proliferation, differentiation and apoptosis. Imbalances within this axis lead to an aberrant signalling and recent research has focussed on the overexpression of these growth factors and their involvement in breast cancer development. The increased understanding of the molecular mechanisms and signalling pathways connected to the GH1/IGF-1 axis has provided important insights into aetiology, prevention and therapy for breast cancer. However, to identify the contribution of the GH1/IGF-1 signalling pathway to cancer risk still remains a challenge since the results of various studies are controversial. Here, we discuss the influence of low-penetrance polymorphisms in the genes along the GH1/IGF-1 axis and their impact on hormone levels and cancer risk, especially breast cancer. We point out what is known about the effects of the variants and show how the interaction of genetic variants affects breast cancer risk.

Objects referenced in this article
Gene IGFBP3 insulin like growth factor binding protein 3 Homo sapiens
Gene Igfbp3 insulin-like growth factor binding protein 3 Mus musculus
Gene Igfbp3 insulin-like growth factor binding protein 3 Rattus norvegicus

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