RGD Reference Report - Neuregulins mediate calcium-induced glucose transport during muscle contraction. - Rat Genome Database
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Neuregulins mediate calcium-induced glucose transport during muscle contraction.

Authors: Canto, C  Chibalin, AV  Barnes, BR  Glund, S  Suarez, E  Ryder, JW  Palacin, M  Zierath, JR  Zorzano, A  Guma, A 
Citation: Canto C, etal., J Biol Chem. 2006 Aug 4;281(31):21690-7. Epub 2006 Jun 1.
RGD ID: 2289995
Pubmed: (View Article at PubMed) PMID:16740635
DOI: Full-text: DOI:10.1074/jbc.M600475200

Neuregulin, a growth factor involved in myogenesis, has rapid effects on muscle metabolism. In a manner analogous to insulin and exercise, neuregulins stimulate glucose transport through recruitment of glucose transporters to surface membranes in skeletal muscle. Like muscle contraction, neuregulins have additive effects with insulin on glucose uptake. Therefore, we examined whether neuregulins are involved in the mechanism by which muscle contraction regulates glucose transport. We show that caffeine-induced increases in cytosolic Ca2+ mediate a metalloproteinase-dependent release of neuregulins, which stimulates tyrosine phosphorylation of ErbB4 receptors. Activation of ErbB4 is necessary for Ca2+-derived effects on glucose transport. Furthermore, blockage of ErbB4 abruptly impairs contraction-induced glucose uptake in slow twitch muscle fibers, and to a lesser extent, in fast twitch muscle fibers. In conclusion, we provide evidence that contraction-induced activation of neuregulin receptors is necessary for the stimulation of glucose transport and a key element of energetic metabolism during muscle contraction.


Gene Ontology Annotations    

Biological Process

Objects Annotated

Genes (Rattus norvegicus)
Erbb4  (erb-b2 receptor tyrosine kinase 4)

Additional Information