RGD Reference Report - Estrogen receptor-binding fragment-associated antigen 9 is a tumor-promoting and prognostic factor for renal cell carcinoma. - Rat Genome Database

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Estrogen receptor-binding fragment-associated antigen 9 is a tumor-promoting and prognostic factor for renal cell carcinoma.

Authors: Ogushi, T  Takahashi, S  Takeuchi, T  Urano, T  Horie-Inoue, K  Kumagai, J  Kitamura, T  Ouchi, Y  Muramatsu, M  Inoue, S 
Citation: Ogushi T, etal., Cancer Res. 2005 May 1;65(9):3700-6.
RGD ID: 2289852
Pubmed: PMID:15867365   (View Abstract at PubMed)
DOI: DOI:10.1158/0008-5472.CAN-04-3497   (Journal Full-text)

The estrogen receptor-binding fragment-associated antigen 9 (EBAG9) has been identified as a primary estrogen-responsive gene in human breast cancer MCF7 cells. A high expression of EBAG9 has been observed in invasive breast cancer and advanced prostate cancer, suggesting a tumor-promoting role of the protein in malignancies. Here we show that intratumoral (i.t.) administration of small interfering RNA against EBAG9 exerted overt regression of tumors following s.c. implantation of murine renal cell carcinoma (RCC) Renca cells. Overexpression of EBAG9 did not promote the proliferation of culture Renca cells; however, the inoculated Renca cells harboring EBAG9 (Renca-EBAG9) in BALB/c mice grew faster and developed larger tumors compared with Renca cells expressing vector alone (Renca-vector). After renal subcapsular implantation, Renca-EBAG9 tumors significantly enlarged compared with Renca-vector tumors in BALB/c mice, whereas both Renca-EBAG9 and Renca-vector tumors were developed with similar volumes in BALB/c nude mice. No apparent difference was observed in specific cytotoxic T-cell responses against Renca-EBAG9 and Renca-vector cells; nonetheless, the number of infiltrating CD8+ T lymphocytes was decreased in Renca-EBAG9 subcapsular tumors. Furthermore, immunohistochemical study of EBAG9 in 78 human RCC specimens showed that intense and diffuse cytoplasmic immunostaining was observed in 87% of the cases and positive EBAG9 immunoreactivity was closely correlated with poor prognosis of the patients. Multivariate analysis revealed that high EBAG9 expression was an independent prognostic predictor for disease-specific survival (P = 0.0485). Our results suggest that EBAG9 is a crucial regulator of tumor progression and a potential prognostic marker for RCC.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
renal cell carcinoma disease_progressionISOEbag9 (Mus musculus)2289852; 2289852 RGD 
renal cell carcinoma disease_progressionIMP 2289852 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ebag9  (estrogen receptor binding site associated antigen 9)

Genes (Mus musculus)
Ebag9  (estrogen receptor-binding fragment-associated gene 9)

Genes (Homo sapiens)
EBAG9  (estrogen receptor binding site associated antigen 9)


Additional Information