RGD Reference Report - Leptin signaling and obesity: cardiovascular consequences. - Rat Genome Database

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Leptin signaling and obesity: cardiovascular consequences.

Authors: Yang, R  Barouch, LA 
Citation: Yang R and Barouch LA, Circ Res. 2007 Sep 14;101(6):545-59.
RGD ID: 2289807
Pubmed: PMID:17872473   (View Abstract at PubMed)
DOI: DOI:10.1161/CIRCRESAHA.107.156596   (Journal Full-text)

Leptin, among the best known hormone markers for obesity, exerts pleiotropic actions on multiple organ systems. In this review, we summarize major leptin signaling pathways, namely Janus-activated kinase/signal transducers and activators of transcription and mitogen-activated protein kinase, including possible mechanisms of leptin resistance in obesity. The effects of leptin on the cardiovascular system are discussed in detail, including its contributions to hypertension, atherosclerosis, depressed myocardial contractile function, fatty acid metabolism, hypertrophic remodeling, and reduction of ischemic/reperfusion injury. The overall goal is to summarize current understanding of how altered leptin signaling in obesity contributes to obesity-related cardiovascular disease.



Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations


  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
PTPN11Humanleptin system pathway   TAS  RGD 
Ptpn11Ratleptin system pathway   ISOPTPN11 (Homo sapiens) RGD 
Ptpn11Mouseleptin system pathway   ISOPTPN11 (Homo sapiens) RGD 
Objects Annotated

Genes (Rattus norvegicus)
Ptpn11  (protein tyrosine phosphatase, non-receptor type 11)

Genes (Mus musculus)
Ptpn11  (protein tyrosine phosphatase, non-receptor type 11)

Genes (Homo sapiens)
PTPN11  (protein tyrosine phosphatase non-receptor type 11)


Additional Information