RGD Reference Report - E-cadherin and alpha-catenin expression during tumor progression of cervical carcinoma. - Rat Genome Database

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E-cadherin and alpha-catenin expression during tumor progression of cervical carcinoma.

Authors: Carico, E  Atlante, M  Bucci, B  Nofroni, I  Vecchione, A 
Citation: Carico E, etal., Gynecol Oncol. 2001 Feb;80(2):156-61.
RGD ID: 2289797
Pubmed: PMID:11161853   (View Abstract at PubMed)
DOI: DOI:10.1006/gyno.2000.6035   (Journal Full-text)

OBJECTIVE: The objective of this study was to determine whether a relationship between the E-caherin molecule and the E-cadherin-associated cytoplasmic molecule, alpha-catenin, could provide additional information in the neoplastic progression of cervical cancer. METHODS: In this study we investigated by immunohistochemistry E-cadherin (E-cad) and alpha-catenin (alpha-cat) expression in 57 cervical biopsy samples representative of normal exocervical epithelium, viral (human papillomavirus (HPV) infection) and dysplastic lesions (low- and high-grade lesions), and invasive squamous cell carcinoma. The presence of immunostaining and the pattern of distribution of these molecules were correlated with the histological diagnosis (normal cervical epithelium vs HPV, cervical intraepithelial neoplasia (CIN), and invasive carcinoma). RESULTS: The correlation between alpha-cat expression and the histological diagnosis was statistically significant (chi2 test, P < 0.0077); moreover, E-cad and alpha-cat distributions were significantly correlated with the histological classification (P < 0.0001 and P < 0.0043, respectively). CONCLUSION: These results suggest that not only E-cad but also alpha-cat are associated with the loss of differentiation in CIN and squamous cell carcinomas; thus the coexpression of E-cad and alpha-cat may represent a discriminant of malignant potential and could provide an additional criterion to define high-grade CIN.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
cervix uteri carcinoma in situ disease_progressionIEP 2289797protein:decreased expression:uterine cervixRGD 
cervix uteri carcinoma in situ disease_progressionISOCTNNA1 (Homo sapiens)2289797; 2289797protein:decreased expression:uterine cervixRGD 
Uterine Cervical Neoplasms  IEP 2289797protein:decreased expression:uterine cervixRGD 
Uterine Cervical Neoplasms  ISOCTNNA1 (Homo sapiens)2289797; 2289797protein:decreased expression:uterine cervixRGD 

Objects Annotated

Genes (Rattus norvegicus)
Ctnna1  (catenin alpha 1)

Genes (Mus musculus)
Ctnna1  (catenin alpha 1)

Genes (Homo sapiens)
CTNNA1  (catenin alpha 1)


Additional Information