RGD Reference Report - [Loss of heterozygosity in the 9p21 region as an inactivation mechanism of the p16 suppressor gene]. - Rat Genome Database

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[Loss of heterozygosity in the 9p21 region as an inactivation mechanism of the p16 suppressor gene].

Authors: Maestro de las Casas, M L  Sanz-Casla, M T  del Barco, V  Moreno, J  Zanna, I  Redondo, E  Fernández, C  Izquierdo, L  Resel Estévez, L 
Citation: Maestro de las Casas ML, etal., Arch Esp Urol. 2000 Sep;53(7):603-9.
RGD ID: 2289689
Pubmed: PMID:11037653   (View Abstract at PubMed)


OBJECTIVE: To determine the loss of heterozygosity (LOH) on 9p21 (locus D9S1747) in patients with renal carcinoma by analysis of microsatellite polymorphisms.
METHODS: 40 patients with sporadic renal cancer were studied. LOH on 9p21 was performed by analysis of microsatellite polymorphisms.
RESULTS: 23.7% showed LOH on 9p21. No correlation was found between this genetic alteration and tumor features.
CONCLUSIONS: LOH on 9p21 was found in 23.7% of the patients in this series. LOH was found in 26.9% of renal cell carcinomas, 25% of papillary carcinomas and 25% of Bellini duct carcinomas. LOH was not found in the other histological types.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Kidney Neoplasms  IAGP 2289689DNA:loss of heterozygosityRGD 
Kidney Neoplasms  ISOCDKN2A (Homo sapiens)2289689; 2289689DNA:loss of heterozygosityRGD 

Objects Annotated

Genes (Rattus norvegicus)
Cdkn2a  (cyclin-dependent kinase inhibitor 2A)

Genes (Mus musculus)
Cdkn2a  (cyclin dependent kinase inhibitor 2A)

Genes (Homo sapiens)
CDKN2A  (cyclin dependent kinase inhibitor 2A)


Additional Information