RGD Reference Report - Expression of the CD44 receptor in the blood vessel system: an experimental study in rat. - Rat Genome Database

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Expression of the CD44 receptor in the blood vessel system: an experimental study in rat.

Authors: Hellstrom, M  Engstrom-Laurent, A  Hellstrom, S 
Citation: Hellstrom M, etal., Cells Tissues Organs. 2005;179(3):102-8.
RGD ID: 2289378
Pubmed: PMID:15947460   (View Abstract at PubMed)
DOI: DOI:10.1159/000085001   (Journal Full-text)

The CD44 receptor is a transmembrane glycoprotein expressed on a variety of cells like endothelial, epithelial and smooth muscle cells. This molecule has many important functions, e.g. in cell-cell and cell-matrix interactions and signal transduction. The main ligand for CD44 is hyaluronan (HYA). HYA is a glycosaminoglycan with structural and cell biological properties. The localization of HYA in the vessel wall of arteries and veins in the healthy adult and newborn rat has been described earlier. In this study the occurrence of the CD44 receptor was investigated in the same vessels and compared to the localization of HYA. Both CD44 and its ligand showed an increased expression in the vessel wall of newborn rats compared to that of adult rats. Although HYA is abundant in the adventitia of adult rats, virtually no expression of CD44 was observed. Our results indicate that the CD44 receptor expression is increased during the stage of maturation of the vessel tree whereas the CD44 receptor is less needed by HYA in the healthy vessel wall.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
blood vessel maturation  IEP 2289378 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cd44  (CD44 molecule)


Additional Information