RGD Reference Report - Quantitative analysis of cyclin E and protein p34 cdc2 expression in superficial bladder cancer. - Rat Genome Database

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Quantitative analysis of cyclin E and protein p34 cdc2 expression in superficial bladder cancer.

Authors: Kaczmarek, P  Tosik, D  Majewska, E  Baj, Z 
Citation: Kaczmarek P, etal., Pol J Pathol. 2006;57(1):41-4.
RGD ID: 2289267
Pubmed: PMID:16739882   (View Abstract at PubMed)

In the present study, the expression of cyclin E and kinase p34 cdc2 was investigated in preinvasive bladder tumors. The study material consisted of bladder sections (grades: GI--16 cases, GII--10, and GIII--12) collected from 38 patients in the course of the tumor electroresection. Immunohistochemical examinations were carried out with immunoperoxidase method. Antigens were labeled with NCL-CYCLIN E or NCL-p34 cdc2 monoclonal antibodies (Novocastra, UK). Positive reaction was demonstrated using ABC-universal Kit (Novocastra, UK). Differences in the protein expression in relation to the tumor grade were determined with a non-parametric Mann-Whitney's test. Increasing grade of tumors was associated with down regulation of cyclin E visible as lower percentage of cyclin E-positive cells. These changes were statistically significant for GI group as compared to groups GII and GIII (p<0.001). There were no differences between the study groups in the p34 protein expression. Cyclin E expression was inversely correlated with tumor grade therefore may be helpful in establishing therapeutic procedure.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
urinary bladder cancer severityIEP 2289267protein:decreased expression:urinary bladderRGD 
urinary bladder cancer severityISOCCNE1 (Homo sapiens)2289267; 2289267protein:decreased expression:urinary bladderRGD 

Objects Annotated

Genes (Rattus norvegicus)
Ccne1  (cyclin E1)

Genes (Mus musculus)
Ccne1  (cyclin E1)

Genes (Homo sapiens)
CCNE1  (cyclin E1)


Additional Information