RGD Reference Report - SynCAMs organize synapses through heterophilic adhesion. - Rat Genome Database

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SynCAMs organize synapses through heterophilic adhesion.

Authors: Fogel, AI  Akins, MR  Krupp, AJ  Stagi, M  Stein, V  Biederer, T 
Citation: Fogel AI, etal., J Neurosci. 2007 Nov 14;27(46):12516-30.
RGD ID: 2289094
Pubmed: PMID:18003830   (View Abstract at PubMed)
PMCID: PMC6673342   (View Article at PubMed Central)
DOI: DOI:10.1523/JNEUROSCI.2739-07.2007   (Journal Full-text)

Synapses are asymmetric cell junctions with precisely juxtaposed presynaptic and postsynaptic sides. Transsynaptic adhesion complexes are thought to organize developing synapses. The molecular composition of these complexes, however, remains incompletely understood, precluding us from understanding how adhesion across the synaptic cleft guides synapse development. Here, we define two immunoglobulin superfamily members, SynCAM 1 and 2, that are expressed in neurons in the developing brain and localize to excitatory and inhibitory synapses. They function as cell adhesion molecules and assemble with each other across the synaptic cleft into a specific, transsynaptic SynCAM 1/2 complex. Additionally, SynCAM 1 and 2 promote functional synapses as they increase the number of active presynaptic terminals and enhance excitatory neurotransmission. The interaction of SynCAM 1 and 2 is affected by glycosylation, indicating regulation of this adhesion complex by posttranslational modification. The SynCAM 1/2 complex is representative for the highly defined adhesive patterns of this protein family, the four members of which are expressed in neurons in divergent expression profiles. SynCAMs 1, 2, and 3 each can bind themselves, yet preferentially assemble into specific, heterophilic complexes as shown for the synaptic SynCAM 1/2 interaction and a second complex comprising SynCAM 3 and 4. Our results define SynCAM proteins as components of novel heterophilic transsynaptic adhesion complexes that set up asymmetric interactions, with SynCAM proteins contributing to synapse organization and function.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Cadm2Ratsynaptic membrane adhesion involved_inIMP PMID:18003830SynGO 
Cadm2Ratsynaptic membrane adhesion involved_inIEP PMID:18003830SynGO 
Cadm2Ratsynaptic membrane adhesion involved_inIDA PMID:18003830SynGO 
Cadm3Ratsynaptic membrane adhesion involved_inIMP PMID:18003830SynGO 
Cadm3Ratsynaptic membrane adhesion involved_inIEP PMID:18003830SynGO 
Cadm3Ratsynaptic membrane adhesion involved_inIDA PMID:18003830SynGO 
Cadm4Ratsynaptic membrane adhesion involved_inIDA PMID:18003830SynGO 
Cadm4Ratsynaptic membrane adhesion involved_inIEP PMID:18003830SynGO 
Cadm4Ratsynaptic membrane adhesion involved_inIMP PMID:18003830SynGO 
Cadm4Ratsynaptic membrane adhesion involved_inNAS PMID:18003830SynGO 

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Cadm2RatGABA-ergic synapse is_active_inIMP PMID:18003830SynGO 
Cadm2RatGABA-ergic synapse is_active_inIEP PMID:18003830SynGO 
Cadm2RatGABA-ergic synapse is_active_inIDA PMID:18003830SynGO 
Cadm3RatGABA-ergic synapse is_active_inIMP PMID:18003830SynGO 
Cadm3RatGABA-ergic synapse is_active_inIEP PMID:18003830SynGO 
Cadm3RatGABA-ergic synapse is_active_inIDA PMID:18003830SynGO 
Cadm2Ratglutamatergic synapse is_active_inIMP PMID:18003830SynGO 
Cadm2Ratglutamatergic synapse is_active_inIEP PMID:18003830SynGO 
Cadm2Ratglutamatergic synapse is_active_inIDA PMID:18003830SynGO 
Cadm3Ratglutamatergic synapse is_active_inIDA PMID:18003830SynGO 
Cadm3Ratglutamatergic synapse is_active_inIMP PMID:18003830SynGO 
Cadm3Ratglutamatergic synapse is_active_inIEP PMID:18003830SynGO 
Cadm2Ratpostsynaptic membrane is_active_inIDA PMID:18003830SynGO 
Cadm2Ratpostsynaptic membrane is_active_inIMP PMID:18003830SynGO 
Cadm2Ratpostsynaptic membrane is_active_inIEP PMID:18003830SynGO 
Cadm4Ratsynaptic membrane is_active_inIDA PMID:18003830SynGO 
Cadm4Ratsynaptic membrane is_active_inIEP PMID:18003830SynGO 

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Cadm1Ratcell adhesion molecule binding  IPIRGD:1313848 RGD 
Cadm1Ratcell adhesion molecule binding  IPIRGD:1322221 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cadm1  (cell adhesion molecule 1)
Cadm2  (cell adhesion molecule 2)
Cadm3  (cell adhesion molecule 3)
Cadm4  (cell adhesion molecule 4)


Additional Information