RGD Reference Report - Circulating microRNAs, miR-21, miR-122, and miR-223, in patients with hepatocellular carcinoma or chronic hepatitis. - Rat Genome Database

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Circulating microRNAs, miR-21, miR-122, and miR-223, in patients with hepatocellular carcinoma or chronic hepatitis.

Authors: Xu, Jian  Wu, Chen  Che, Xu  Wang, Li  Yu, Dianke  Zhang, Tongwen  Huang, Liming  Li, Hui  Tan, Wen  Wang, Chengfeng  Lin, Dongxin 
Citation: Xu J, etal., Mol Carcinog. 2011 Feb;50(2):136-42. doi: 10.1002/mc.20712. Epub 2010 Dec 10.
RGD ID: 21408591
Pubmed: PMID:21229610   (View Abstract at PubMed)
DOI: DOI:10.1002/mc.20712   (Journal Full-text)

Numerous studies have shown that aberrant microRNA (miRNA) expression is associated with the development and progression of various types of human cancer and serum miRNAs are potential biomarkers. This study examined whether some commonly deregulated miRNAs in hepatocellular carcinoma (HCC) are presented in serum of patients with HCC and can serve as diagnostic markers. Serum miRNAs (miR-21, miR-122, and miR-223) were quantified by real-time quantitative RT-PCR in 101 patients with HCC and 89 healthy controls. In addition, 48 patients with chronic type B hepatitis were also analyzed for comparison. We found that the median levels of miR-21, miR-122, and miR-223 were significantly higher in patients with HCC than those in healthy controls (P = 7.48 x 10⁻¹³, P = 6.93 x 10⁻⁹, and P = 3.90 x 10⁻¹², respectively). However, these elevated serum miRNAs were also detected in patients with chronic hepatitis (P = 2.05 x 10⁻¹², P = 4.52 x 10⁻¹⁶, and P = 1.65 x 10⁻¹¹, respectively). Moreover, serum miR-21 and miR-122 in patients with chronic hepatitis were higher than in patients with HCC (P = 3.99 x  10⁻⁴ and P = 4.97 x 10⁻⁸), although no such significant difference was found for miR-223. Receiver-operator characteristic (ROC) curve analyses suggest that these serum miRNAs may be useful markers for discriminating patients with HCC or chronic hepatitis from healthy controls, but not patients with HCC from patients with chronic hepatitis. Our results indicate that serum miR-21, miR-122 and miR-223 are elevated in patients with HCC or chronic hepatitis and these miRNAs have strong potential to serve as novel biomarkers for liver injury but not specifically for HCC.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
hepatocellular carcinoma  IEP 21408591RNA:increased expression:serum:RGD 
hepatocellular carcinoma  ISOMIR223 (Homo sapiens)21408591; 21408591RNA:increased expression:serum:RGD 

Objects Annotated

Genes (Rattus norvegicus)
Mir223  (microRNA 223)

Genes (Mus musculus)
Mir223  (microRNA 223)

Genes (Homo sapiens)
MIR223  (microRNA 223)


Additional Information