RGD Reference Report - Serum levels of miR-29, miR-122, miR-155 and miR-192 are elevated in patients with cholangiocarcinoma. - Rat Genome Database

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Serum levels of miR-29, miR-122, miR-155 and miR-192 are elevated in patients with cholangiocarcinoma.

Authors: Loosen, Sven H  Lurje, Georg  Wiltberger, Georg  Vucur, Mihael  Koch, Alexander  Kather, Jakob N  Paffenholz, Pia  Tacke, Frank  Ulmer, Florian T  Trautwein, Christian  Luedde, Tom  Neumann, Ulf P  Roderburg, Christoph 
Citation: Loosen SH, etal., PLoS One. 2019 Jan 17;14(1):e0210944. doi: 10.1371/journal.pone.0210944. eCollection 2019.
RGD ID: 21081530
Pubmed: PMID:30653586   (View Abstract at PubMed)
PMCID: PMC6336320   (View Article at PubMed Central)
DOI: DOI:10.1371/journal.pone.0210944   (Journal Full-text)


OBJECTIVES: Cholangiocarcinoma (CCA) represents the second most common primary hepatic malignancy. Despite tremendous research activities, the prognosis for the majority of patients is still poor. Only in case of early diagnosis, liver resection might potentially lead to long-term survival. However, it is still unclear which patients benefit most from extensive liver surgery, highlighting the need for new diagnostic and prognostic stratification strategies.
METHODS: Serum concentrations of a 4 miRNA panel (miR-122, miR-192, miR-29b and miR-155) were analyzed using semi-quantitative reverse-transcriptase PCR in serum samples from 94 patients with cholangiocarcinoma undergoing tumour resection and 40 healthy controls. Results were correlated with clinical data.
RESULTS: Serum concentrations of miR-122, miR-192, miR-29b and miR-155 were significantly elevated in patients with CCA compared to healthy controls or patients with primary sclerosing cholangitis without malignant transformation. Although preoperative levels of these miRNAs were unsuitable as a prognostic marker of survival, a strong postoperative decline of miR-122 serum levels was significantly associated with a favorable patients' prognosis.
CONCLUSIONS: Analysis of circulating miRNAs represents a promising tool for the diagnosis of even early stage CCA. A postoperative decline in miRNA serum concentrations might be indicative for a favorable patients' outcome and helpful to identify patients with a good prognosis after extended liver surgery.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
cholangiocarcinoma  IEP 21081530miRNA:increased expression:serumRGD 
cholangiocarcinoma  ISOMIR155 (Homo sapiens)21081530; 21081530miRNA:increased expression:serumRGD 
primary sclerosing cholangitis  IEP 21081530miRNA:decreased expression:serumRGD 
primary sclerosing cholangitis  ISOMIR155 (Homo sapiens)21081530; 21081530miRNA:decreased expression:serumRGD 

Objects Annotated

Genes (Rattus norvegicus)
Mir155  (microRNA 155)

Genes (Mus musculus)
Mir155  (microRNA 155)

Genes (Homo sapiens)
MIR155  (microRNA 155)


Additional Information