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MicroRNA-152 Acts as a Tumor Suppressor MicroRNA by Inhibiting Krüppel-Like Factor 5 in Human Cervical Cancer.

Authors: Zhang, Haiyan  Lu, Yanxia  Wang, Surong  Sheng, Xiugui  Zhang, Shiqian 
Citation: Zhang H, etal., Oncol Res. 2019 Feb 21;27(3):335-340. doi: 10.3727/096504018X15252202178408. Epub 2018 Aug 21.
Pubmed: (View Article at PubMed) PMID:30131089
DOI: Full-text: DOI:10.3727/096504018X15252202178408

Aberrant expression of microRNA-152 (miR-152) is frequently observed in human cancers including ovarian cancer, breast cancer, prostate cancer, and gastric cancer. However, its expression and functional role in cervical cancer (CC) are poorly understood. Also, the association between miR-152 and Krüppel-like factor 5 (KLF5) expression in CC remains unclear. In this study, analyzing the expression of miR-152 by quantitative real-time PCR (qRT-PCR) revealed it was sharply reduced in CC tissues and cell lines. In addition, the negative correlation of miR-152 expression and KLF5 expression was observed. The dual-luciferase reporter assay validated that KLF5 was a target of miR-152. In vitro functional assays revealed that miR-152 could inhibit cell proliferation and cell cycle progression through regulating the expression of KLF5. Taken together, our study suggested that miR-152 functions as a tumor suppressor in CC, and the miR-152/KLF5 axis may provide novel therapeutic targets for CC treatment.


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RGD Object Information
RGD ID: 19165142
Created: 2020-02-04
Species: All species
Last Modified: 2020-02-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.