RGD Reference Report - NEURL rs6584555 and CAND2 rs4642101 contribute to postoperative atrial fibrillation: a prospective study among Chinese population. - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

NEURL rs6584555 and CAND2 rs4642101 contribute to postoperative atrial fibrillation: a prospective study among Chinese population.

Authors: Wei, Tiemin  Song, Jingjing  Xu, Min  Lv, Lingchun  Liu, Chong  Shen, Jiayi  Huang, Ying 
Citation: Wei T, etal., Oncotarget. 2016 Jul 5;7(27):42617-42624. doi: 10.18632/oncotarget.9422.
RGD ID: 18899562
Pubmed: (View Article at PubMed) PMID:27203392
DOI: Full-text: DOI:10.18632/oncotarget.9422

Postoperative atrial fibrillation (POAF) is a serious, common complication after coronary artery bypass grafting (CABG) surgery. Recently, 5 novel loci were identified to be associated with atrial fibrillation susceptibility using a combination of genotyping, eQTL mapping, and functional validation. In current study, we aim to evaluated the positive findings for POAF susceptibility after CABG among Chinese population, using a population-based, two-stage, nested case-control study with 1,400 patients. NEURL rs12415501 and CAND2 rs4642101 were significantly associated with POAF susceptibility after CABG among Chinese population in both stages. When pooled together, the ORs for each additional copy of minor allele was 1.29 (95% CI: 1.13-1.48, P = 1.7×10-4) for NEURL rs12415501, and 1.21 (95% CI: 1.08-1.36, P = 9.8×10-4) for CAND2 rs4642101. Functional validation experiments found the AF risk allele of NEURL rs6584555 and CAND2 rs4642101 correlated with an increased expression of its corresponding genes (P<0.001). In this independently collected cardiac surgery cohort, we replicated the previous findings, and 2 novel loci are independently associated with POAF risk in patients who undergo CABG surgery in Chinese population.

Annotation

Disease Annotations    

Objects Annotated

Genes (Rattus norvegicus)
Cand2  (cullin-associated and neddylation-dissociated 2 (putative))

Genes (Mus musculus)
Cand2  (cullin-associated and neddylation-dissociated 2 (putative))

Genes (Homo sapiens)
CAND2  (cullin associated and neddylation dissociated 2 (putative))


Additional Information