RGD Reference Report - Evaluation of LEXF/FXLE rat recombinant inbred strains for the genetic dissection of complex traits. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

Evaluation of LEXF/FXLE rat recombinant inbred strains for the genetic dissection of complex traits.

Authors: Voigt, B  Kuramoto, T  Mashimo, T  Tsurumi, T  Sasaki, Y  Hokao, R  Serikawa, T 
Citation: Voigt B, etal., Physiol Genomics. 2007 Nov 27;.
RGD ID: 1643429
Pubmed: PMID:18042833   (View Abstract at PubMed)
DOI: DOI:10.1152/physiolgenomics.00158.2007   (Journal Full-text)

Recombinant inbred (RI) strains are formed from an outcross between two well-characterized inbred stains followed by at least 20 generations of inbreeding. RI strains can be utilized for the analysis of many complex phenotypic traits. The LEXF/FXLE RI strain set consists of 34 RI strains derived by reciprocal crossing of LE/Stm and F344/Stm. Here, we report on genetic dissections of complex traits using this RI set and their parental strains. We have developed strain distribution patterns for 232 informative SSLP markers. The framework map covers the rat genome except for chromosome Y. Seventy-six phenotype parameters, which included physiological and behavioral traits, were examined for these recombinant inbred lines. The QTL analysis of these parameters revealed 27 significant and 91 suggestive quantitative trait loci, illustrating the potential of this RI resource for the detection of underlying gene functions for various phenotypes. Although this RI set was originally developed to study susceptibility toward chemical-induced tumors, it has been shown to be equally powerful for a wide spectrum of traits. The LEXF/FXLE RI strains have been deposited at the National Bio Resource Project for the Rat in Japan and are maintained under SPF conditions. They are available at http://www.anim.med.kyoto-u.ac.jp/nbr. Key words: Rattus norvegicus, recombinant inbred rats, QTL mapping, physiological traits, genetic.



Objects referenced in this article
Strain FXLE/Stm null Rattus norvegicus
Strain FXLE12/Stm null Rattus norvegicus
Strain FXLE13/Stm null Rattus norvegicus
Strain FXLE14/Stm null Rattus norvegicus
Strain FXLE15/Stm null Rattus norvegicus
Strain FXLE16/Stm null Rattus norvegicus
Strain FXLE17/Stm null Rattus norvegicus
Strain FXLE18/Stm null Rattus norvegicus
Strain FXLE19/Stm null Rattus norvegicus
Strain FXLE20/Stm null Rattus norvegicus
Strain FXLE21/Stm null Rattus norvegicus
Strain FXLE22/Stm null Rattus norvegicus
Strain FXLE23/Stm null Rattus norvegicus
Strain FXLE24/Stm null Rattus norvegicus
Strain FXLE25/Stm null Rattus norvegicus
Strain FXLE26/Stm null Rattus norvegicus
Strain LEXF/Stm null Rattus norvegicus
Strain LEXF10A/Stm null Rattus norvegicus
Strain LEXF10B/Stm null Rattus norvegicus
Strain LEXF10C/Stm null Rattus norvegicus
Strain LEXF11/Stm null Rattus norvegicus
Strain LEXF1A/Stm null Rattus norvegicus
Strain LEXF1C/Stm null Rattus norvegicus
Strain LEXF2A/Stm null Rattus norvegicus
Strain LEXF2B/Stm null Rattus norvegicus
Strain LEXF2C/Stm null Rattus norvegicus
Strain LEXF3/Stm null Rattus norvegicus
Strain LEXF4/Stm null Rattus norvegicus
Strain LEXF5/Stm null Rattus norvegicus
Strain LEXF6B/Stm null Rattus norvegicus
Strain LEXF7A/Stm null Rattus norvegicus
Strain LEXF7B/Stm null Rattus norvegicus
Strain LEXF7C/Stm null Rattus norvegicus
Strain LEXF8A/Stm null Rattus norvegicus
Strain LEXF8D/Stm null Rattus norvegicus
Strain LEXF9/Stm null Rattus norvegicus

Additional Information