RGD Reference Report - Differential stimulation of PKC phosphorylation of potassium channels by ZIP1 and ZIP2. - Rat Genome Database

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Differential stimulation of PKC phosphorylation of potassium channels by ZIP1 and ZIP2.

Authors: Gong, J  Xu, J  Bezanilla, M  Van Huizen, R  Derin, R  Li, M 
Citation: Gong J, etal., Science. 1999 Sep 3;285(5433):1565-9.
RGD ID: 1642693
Pubmed: PMID:10477520   (View Abstract at PubMed)

Targeting of protein modification enzymes is a key biochemical step to achieve specific and effective posttranslational modifications. Two alternatively spliced ZIP1 and ZIP2 proteins are described, which bind to both Kvbeta2 subunits of potassium channel and protein kinase C (PKC) zeta, thereby acting as a physical link in the assembly of PKCzeta-ZIP-potassium channel complexes. ZIP1 and ZIP2 differentially stimulate phosphorylation of Kvbeta2 by PKCzeta. They also interact to form heteromultimers, which allows for a hybrid stimulatory activity to PKCzeta. Finally, ZIP1 and ZIP2 coexist in the same cell type and are elevated differentially by neurotrophic factors. These results provide a mechanism for specificity and regulation of PKCzeta-targeted phosphorylation.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
positive regulation of protein phosphorylation  IDA 1642693 RGD 
protein phosphorylation  IDA 1642693 RGD 

Molecular Function

Objects Annotated

Genes (Rattus norvegicus)
Kcnab2  (potassium voltage-gated channel subfamily A regulatory beta subunit 2)
Prkcz  (protein kinase C, zeta)
Sqstm1  (sequestosome 1)


Additional Information