RGD Reference Report - Contents of D-lactate and its related metabolites as well as enzyme activities in the liver, muscle and blood plasma of aging rats. - Rat Genome Database

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Contents of D-lactate and its related metabolites as well as enzyme activities in the liver, muscle and blood plasma of aging rats.

Authors: Kawase, M  Kondoh, C  Matsumoto, S  Teshigawara, M  Chisaka, Y  Higashiura, M  Nakata, K  Ohmori, S 
Citation: Kawase M, etal., Mech Ageing Dev. 1995 Sep 29;84(1):55-63.
RGD ID: 1641958
Pubmed: PMID:8719777   (View Abstract at PubMed)

As it is generally known. L-lactate is formed via the Embden-Meyerhof glycolytic pathway from triosephosphates, whereas D-lactate is formed via methylglyoxal in rat. In this paper, age-related changes in the levels of D-lactate and its related compounds in rat tissues are reported. Rats from 5 weeks to 30 months old were used in these experiments. (1) We observed that rats above 27 months old were decrepit as judged by external appearance movement and other physiological data of them. (2) The hepatic levels of D-lactate, methylglyoxal and pyruvate became markedly lower in aging rats, especially the D-lactate content in 30 month-old rats was lower by 90% than that of the 5 week-old rats. (3) As for plasma, D-lactate and phosphate levels became lower with aging, whereas levels of L-lactate and pyruvate were not altered. (4) In skeletal muscle, aging caused a lower methylglyoxal concentration. The D-lactate level was markedly decreased at the age of 30 months in muscle. (5) As for enzyme, activities of glyoxalase I and II became markedly decreased with age in livers, whereas the activity of glyoxalase I in muscle was maintained at control level and glyoxalase II increased with age.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
glutathione metabolic process  IDA 1641958; 1641958 RGD 
methylglyoxal metabolic process  IDA 1641958 RGD 

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
hydroxyacylglutathione hydrolase activity  IDA 1641958 RGD 
lactoylglutathione lyase activity  IDA 1641958 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Glo1  (glyoxalase 1)
Hagh  (hydroxyacyl glutathione hydrolase)


Additional Information