RGD Reference Report - Reduced apelin levels in lone atrial fibrillation. - Rat Genome Database

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Reduced apelin levels in lone atrial fibrillation.

Authors: Ellinor, PT  Low, AF  MacRae, CA 
Citation: Ellinor PT, etal., Eur Heart J. 2006 Jan;27(2):222-6. Epub 2005 Nov 8.
RGD ID: 1626174
Pubmed: PMID:16278229   (View Abstract at PubMed)
DOI: DOI:10.1093/eurheartj/ehi648   (Journal Full-text)

AIMS: Apelin is an endogenous peptide hormone that appears to have a physiological role in counter-regulation of the angiotensin and vasopressin systems. This peptide has been reported to be down-regulated in subjects with acute heart failure, but has not been studied in other cardiovascular conditions. We studied apelin levels in 73 subjects with lone atrial fibrillation (AF). METHODS AND RESULTS: Study subjects had electrocardiographic evidence of paroxysmal or chronic AF and a structurally normal heart on echocardiography. Subjects were excluded if they had a history of coronary artery disease, rheumatic heart disease, cardiomyopathy, significant valvular disease, hyperthyroidism, or antecedent hypertension. Controls were recruited from a healthy outpatient population. Plasma apelin levels were determined using a commercially available immunoassay. Seventy-three subjects with lone AF and 73 healthy controls were enrolled and studied. Mean levels of apelin were significantly lower in subjects with lone AF when compared with controls (307 vs. 648 pg/mL, P<0.00005). CONCLUSION: Reduced apelin levels were observed in this homogenous population of lone AF subjects and may represent an underlying diathesis predisposing to this common arrhythmia.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
atrial fibrillation  IEP 1626174protein:decreased expression:plasmaRGD 
atrial fibrillation  ISOAPLN (Homo sapiens)1626174; 1626174protein:decreased expression:plasmaRGD 

Objects Annotated

Genes (Rattus norvegicus)
Apln  (apelin)

Genes (Mus musculus)
Apln  (apelin)

Genes (Homo sapiens)
APLN  (apelin)


Additional Information