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Reduced ciliary neuronotrophic factor-like activity in nerves from diabetic or galactose-fed rats.

Authors: Calcutt, NA  Muir, D  Powell, HC  Mizisin, AP 
Citation: Calcutt NA, etal., Brain Res. 1992 Mar 20;575(2):320-4.
Pubmed: (View Article at PubMed) PMID:1571789

This study examined the levels of ciliary neuronotrophic factor (CNTF)-like activity in the sciatic nerve of rats with short-term streptozotocin-induced diabetes or dietary supplementation with 40% galactose. CNTF-like activity, found in nerve extracts by in vitro bioassay, was reduced to 20% of control values after 1 or 2 months of galactose feeding (both P less than 0.01) and to 70% of control values after two months of streptozotocin diabetes (P less than 0.01). These data demonstrate that short-term hyperglycemia or its consequences can reduce extractable levels of Schwann cell-derived neuronotrophic factor and raise the possibility that impaired Schwann cell production of CNTF may contribute to the development of experimental diabetic neuropathy.


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RGD Object Information
RGD ID: 1626119
Created: 2007-07-12
Species: All species
Last Modified: 2007-07-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.