RGD Reference Report - Lipolysis and apoptosis of adipocytes induced by neuropeptide Y-Y5 receptor antisense oligodeoxynucleotides in obese rats. - Rat Genome Database

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Lipolysis and apoptosis of adipocytes induced by neuropeptide Y-Y5 receptor antisense oligodeoxynucleotides in obese rats.

Authors: Gong, HX  Guo, XR  Fei, L  Guo, M  Liu, QQ  Chen, RH 
Citation: Gong HX, etal., Acta Pharmacol Sin. 2003 Jun;24(6):569-75.
RGD ID: 1625499
Pubmed: PMID:12791184   (View Abstract at PubMed)

AIM: To investigate the influence of central administration of neuropeptide Y-Y5 receptor antisense oligodeoxynucleotides (ODN) on the body weight and fat pads of high-energy diet-induced obese rats, and the effects on white adipocyte lipolysis and apoptosis. METHODS: Y5 receptor antisense, sense, mismatched oligodeoxynucleotides (ODN) or vehicle were intracerebroventricularly injected, and average adipocyte area was calculated. DNA ladders were measured to evaluate adipocyte apoptosis, and RT-PCR was used to analyze the expression of bcl-2 and bax gene. RESULTS: (1) Central administration of Y5 receptor antisense ODN significantly decreased body weight, fat pads, and average adipocyte area. (2) DNA fragmentation was presented after electrophoresis at both epididymal and retroperitoneal adipose tissue. (3) The expression of bcl-2 gene was downregulated, while the expression of bax was upregulated. CONCLUSION: Lipolysis and adipocyte apoptosis may be important reasons for Y5 receptor antisense therapy.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
negative regulation of apoptotic process  IMP 1625499 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Npy5r  (neuropeptide Y receptor Y5)


Additional Information