RGD Reference Report - Do allelic variants in alpha2A and alpha2C adrenergic receptors predispose to hypertension in blacks? - Rat Genome Database

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Do allelic variants in alpha2A and alpha2C adrenergic receptors predispose to hypertension in blacks?

Authors: Li, JL  Canham, RM  Vongpatanasin, W  Leonard, D  Auchus, RJ  Victor, RG 
Citation: Li JL, etal., Hypertension. 2006 Jun;47(6):1140-6. Epub 2006 Apr 24.
RGD ID: 1625183
Pubmed: PMID:16636200   (View Abstract at PubMed)
DOI: DOI:10.1161/01.HYP.0000217972.80731.ef   (Journal Full-text)

Sequence variations in the human alpha2 adrenergic receptor genes (ADRA2A and ADRA2C) have been implicated as a cause of hypertension in blacks. Although certain alleles are selectively enriched in blacks, their association with hypertension is based on small convenience samples and has not been evaluated in larger populations. From a stratified random population sample of 3398 individuals (52% blacks), we obtained DNA samples together with an in-home health interview, 10 in-home measurements of blood pressure, and cardiac MRI. We tested for associations among hypertension, untreated blood pressure, and parameters of hypertensive heart disease with 2 alleles, a DraI restriction fragment length polymorphism in the ADRA2A gene and a deletion of residues 322 to 325 in the ADRA2C gene. Although both alleles were selectively enriched in this black population, we found no association of either allele with hypertension, untreated blood pressure, or any of the cardiac function parameters. In a logistic model that controlled for age, body mass index, diabetes, and smoking, the adjusted odds ratio (OR) for hypertension was 1.0 (95% CI, 0.8 to 1.2), and 1.0 (95% CI, 0.9 to 1.2) for ADRA2A and ADRA2C variant alleles. In subjects not receiving prescription blood pressure medication, neither of these alleles, alone or in combination, was predictive of blood pressure, heart rate, left ventricular mass, cardiac output, systemic vascular resistance, or aortic compliance. Both the DraI restriction fragment length polymorphism in ADRA2A and the ADRA2C (Del 322 to 325) can be excluded as major candidate alleles for hypertension in blacks.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
hypertension no_associationIAGP 1625183DNA:polymorphismRGD 
hypertension no_associationISOADRA2A (Homo sapiens)1625183; 1625183DNA:polymorphismRGD 

Objects Annotated

Genes (Rattus norvegicus)
Adra2a  (adrenoceptor alpha 2A)

Genes (Mus musculus)
Adra2a  (adrenergic receptor, alpha 2a)

Genes (Homo sapiens)
ADRA2A  (adrenoceptor alpha 2A)


Additional Information