RGD Reference Report - Quantitative trait loci determining weight reduction of testes and pituitary by diethylstilbesterol in LEXF and FXLE recombinant inbred strain rats. - Rat Genome Database

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Quantitative trait loci determining weight reduction of testes and pituitary by diethylstilbesterol in LEXF and FXLE recombinant inbred strain rats.

Authors: Tachibana, M  Lu, L  Hiai, H  Tamura, A  Matsushima, Y  Shisa, H 
Citation: Tachibana M, etal., Exp Anim. 2006 Apr;55(2):91-5.
RGD ID: 1625009
Pubmed: PMID:16651691   (View Abstract at PubMed)

Increasing exposure to environmental endocrine disruptor, xeno-estrogen, is a serious hazard to male reproductive activity. To explore possible genetic control in susceptibility to xeno-estrogen, the weight reduction of testes induced by the continuous administration of a synthetic estrogen, diethylstilbesterol, were investigated by quantitative trait analysis in LEXF and FXLE recombinant inbred strain rats, consisting of 21 independent strains, 9 of their substrains, parental F344/Stm and LE/Stm strains, and (F344 x LE)F1. For the weight of testes, one highly significant quantitative trait locus (QTL) and one significant QTL were mapped on chromosomes 7 and 1, respectively. The QTL on chromosome 7 is closely associated with c-myc. Pituitary weight and serum prolactin were also variable among recombinant inbred strains, but no QTL was detected for them in this study.



Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Teswt1Ratdecreased testis weight  IDA  RGD 
Teswt2Ratdecreased testis weight  IDA  RGD 

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Rat Strains:
Clinical Measurements:
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Measurement Methods:
Objects Annotated

QTLs
Teswt1  (Testicular weight QTL 1)
Teswt2  (Testicular weight QTL 2)

Strains
LEXF/Stm  (NA)

Objects referenced in this article
Strain FXLE/Stm null Rattus norvegicus

Additional Information