RGD Reference Report - Ghrelin augments afferent response to distension in rat isolated jejunum. - Rat Genome Database

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Ghrelin augments afferent response to distension in rat isolated jejunum.

Authors: Murray, CD  Booth, CE  Bulmer, DC  Kamm, MA  Emmanuel, AV  Winchester, WJ 
Citation: Murray CD, etal., Neurogastroenterol Motil. 2006 Dec;18(12):1112-20.
RGD ID: 1624382
Pubmed: (View Article at PubMed) PMID:17109695
DOI: Full-text: DOI:10.1111/j.1365-2982.2006.00848.x

Ghrelin has been shown to decrease firing of gastric vagal afferents at doses comparable with circulating levels in the fasted state. This raises the possibility that ghrelin may have a hormonal action on other vagal afferent populations. The aim of this study was to determine the effects of ghrelin on jejunal afferent activity; including responses to distension, 2-methyl-5-hydroxytryptamine (2-methyl-5-HT) and cholecystokinin (CCK) in both naive and vagotomized rats. Ghrelin significantly augmented the afferent response to distension. No effect was observed on baseline afferent discharge, or the response to 2-methyl-5-HT and CCK. The effect of ghrelin was more pronounced at lower ramp distending pressures (0-30 mmHg). Similarly, ghrelin augmented the jejunal afferent responses to phasic distension at 10-30 mmHg, but had no effect at higher pressures. Chronic subdiaphragmatic vagotomy and administration of the growth hormone secretagogue receptor (GHS-R) antagonist [D-Lys3]-GHRP-6 prevented the augmentation of the afferent responses to distension indicating ghrelin is acting through the GHS-R on vagal afferent fibres. Ghrelin augments the mechanosensation of jejunal vagal afferents and hence may lead to increased perception of hunger contractions.

Gene Ontology Annotations    

Molecular Function

Objects Annotated

Genes (Rattus norvegicus)
Ghrl  (ghrelin and obestatin prepropeptide)
Ghsr  (growth hormone secretagogue receptor)

Additional Information