RGD Reference Report - Disruption of the architectural factor HMGI-C: DNA-binding AT hook motifs fused in lipomas to distinct transcriptional regulatory domains. - Rat Genome Database
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Disruption of the architectural factor HMGI-C: DNA-binding AT hook motifs fused in lipomas to distinct transcriptional regulatory domains.

Authors: Ashar, HR  Fejzo, MS  Tkachenko, A  Zhou, X  Fletcher, JA  Weremowicz, S  Morton, CC  Chada, K 
Citation: Ashar HR, etal., Cell. 1995 Jul 14;82(1):57-65.
RGD ID: 1601567
Pubmed: (View Article at PubMed) PMID:7606786

Lipomas are one of the most common mesenchymal neoplasms in humans. They are characterized by consistent cytogenetic aberrations involving chromosome 12 in bands q14-15. Interestingly, this region is also the site of rearrangement for other mesenchymally derived tumors. This study demonstrates that HMGI-C, an architectural factor that functions in transcriptional regulation, has been disrupted by rearrangement at the 12q14-15 chromosomal breakpoint in lipomas. Chimeric transcripts were isolated from two lipomas in which HMGI-C DNA-binding domains (AT hook motifs) are fused to either a LIM or an acidic transactivation domain. These results, identifying a gene rearranged in a benign neoplastic process that does not proceed to a malignancy, suggest a role for HMGI-C in adipogenesis and mesenchyme differentiation.

Annotation

Disease Annotations    
lipoma  (IAGP,ISO)

Objects Annotated

Genes (Rattus norvegicus)
Hmga2  (high mobility group AT-hook 2)

Genes (Mus musculus)
Hmga2  (high mobility group AT-hook 2)

Genes (Homo sapiens)
HMGA2  (high mobility group AT-hook 2)


Additional Information