RGD Reference Report - Effects of estrogen and growth hormone on steroid sulfatase activity and estrogen binding in rat liver. - Rat Genome Database

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Effects of estrogen and growth hormone on steroid sulfatase activity and estrogen binding in rat liver.

Authors: Nilsson, B  Carlstrom, K  Von Schoultz, B 
Citation: Nilsson B, etal., J Steroid Biochem. 1988 Mar;29(3):293-5.
RGD ID: 1601403
Pubmed: PMID:2965775   (View Abstract at PubMed)

It is now well established that the activity of certain liver enzymes displays sex differences and that administration of human growth hormone to male rats alters the liver metabolism in a "female" direction. In this work we studied steroid sulfatase activity and binding of estradiol-17 beta in livers from intact rats and found a sex difference, with considerably higher enzyme activity in male as compared to female liver tissue. Continuous infusion of native and recombinant human growth hormone and estradiol-17 beta to male rats reduced sulfatase activity to "female" levels. A specific binding of estradiol-17 beta with receptor properties was found in the rat livers, but the concentration of binding sites did not change after administration of growth hormone or estradiol in this group of intact animals. Our data confirm previous reports that continuous administration of human growth hormone "feminize" liver metabolism, and since estradiol was found to have an identical effect on sulfatase activity it is suggested that the effect of estradiol-17 beta in this respect may be indirect, mediated via an altered secretory pattern of rat growth hormone.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
response to estrogen  IDA 1601403 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Sts  (steroid sulfatase)


Additional Information