RGD Reference Report - Effect of selenium and vitamin E deficiency on differential gene expression in rat liver. - Rat Genome Database

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Effect of selenium and vitamin E deficiency on differential gene expression in rat liver.

Authors: Fischer, A  Pallauf, J  Gohil, K  Weber, SU  Packer, L  Rimbach, G 
Citation: Fischer A, etal., Biochem Biophys Res Commun. 2001 Jul 13;285(2):470-5.
RGD ID: 1601045
Pubmed: PMID:11444866   (View Abstract at PubMed)
DOI: DOI:10.1006/bbrc.2001.5171   (Journal Full-text)

To examine the molecular events associated with selenium (Se) and vitamin E (VE) deficiency, we applied cDNA array technology to define the transcriptional response in the liver of Se- and VE-deficient rats. VE deficiency alone did not induce any significant changes in expression profile among the genes evaluated. Se deficiency lead to a down-regulation of Se-dependent cGPx and to an induction of genes, encoding for detoxifying enzymes in liver (cytochrome P450 4B1, UDP-glucuronosyltransferase 1). Combined VE and Se deficiency was characterized by alterations in the expression level of genes encoding for proteins involved in inflammation (multispecific organic anion exporter, SPI-3 serine protease inhibitor) and acute phase response (alpha-1 acid glycoprotein, metallothionein 1). Additionally, a significant down-regulation in the expression level of genes important in the inhibition of apoptosis (defender against cell death 1 protein, Bcl2-L1), cell cycle (G1/S-specific cyclin D1) and antioxidant defense (gamma-glutamylcysteine synthetase catalytic subunit) was demonstrated. The experimental strategy identified several novel Se and VE sensitive genes.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
response to nutrient  IEP 1601045 RGD 
response to vitamin E  IEP 1601045 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Dad1  (defender against cell death 1)
Orm1  (orosomucoid 1)


Additional Information