RGD Reference Report - Strain differences in the distribution of dopamine (DA-2 and DA-3) receptor sites in rat brain. - Rat Genome Database

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Strain differences in the distribution of dopamine (DA-2 and DA-3) receptor sites in rat brain.

Authors: Yaroslavsky, I  Colletti, M  Jiao, X  Tejani-Butt, S 
Citation: Yaroslavsky I, etal., Life Sci. 2006 Jul 17;79(8):772-6. Epub 2006 Mar 30.
RGD ID: 1600945
Pubmed: PMID:16574158   (View Abstract at PubMed)
DOI: DOI:10.1016/j.lfs.2006.02.030   (Journal Full-text)

The dopamine (DA) pathway mediates numerous neuronal functions which are implicated in psychiatric disorders. Previously, our lab investigated the status of the dopamine transporter in the Wistar-Kyoto rat, a purported rodent model of depressive behavior, and reported significant alterations in transporter binding sites in several brain regions when compared to control rat strains. Given that DA-2 and DA-3 receptors belong to the same class of DA receptors, are co-localized in the mesolimbic and nigrostriatal regions of the brain and function as autoreceptors, this study mapped the distribution of central DA-2 and DA-3 receptors in Wistar-Kyoto and Wistar rats. The results indicated that while the binding of 125I-sulpride to DA-2 receptors was higher in the nucleus accumbens (shell) and ventral tegmental area, it was lower in the nucleus accumbens (core), caudate putamen and hypothalamus in Wistar-Kyoto compared to Wistar rats. In contrast, the binding of 125I-sulpride to DA-3 receptors was higher in the caudate putamen, nucleus accumbens (shell and core) and islands of Calleja in Wistar-Kyoto compared to Wistar rats. Given that DA-2 like receptors in the ventral tegmental area function as autoreceptors, it is possible that the greater inhibitory effects exerted by DA-2 and DA-3 receptors in Wistar-Kyoto rats may lead to a net deficit in DA levels in areas receiving projection from this cell body area.

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Gene Drd2 dopamine receptor D2 Rattus norvegicus

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