RGD Reference Report - Protective function of complement against alcohol-induced rat liver damage. - Rat Genome Database

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Protective function of complement against alcohol-induced rat liver damage.

Authors: Bykov, IL  Vakeva, A  Jarvelainen, HA  Meri, S  Lindros, KO 
Citation: Bykov IL, etal., Int Immunopharmacol. 2004 Nov;4(12):1445-54.
RGD ID: 1600673
Pubmed: PMID:15351314   (View Abstract at PubMed)
DOI: DOI:10.1016/j.intimp.2004.06.008   (Journal Full-text)

The complement system can promote tissue damage or play a homeostatic role in the clearance and disposal of damaged tissue. We assessed the role of the terminal complement pathway in alcohol-induced liver damage in complement C6 (C6-/-) genetically deficient rats. C6-/- and corresponding C6+/+ rats were continuously exposed to ethanol by feeding ethanol-supplemented liquid diet for six weeks. Liver samples were analyzed for histopathology and complement component deposition by immunofluorescence microscopy. Prostaglandin E receptors and cytokine mRNA levels were analyzed by RT-PCR and plasma cytokines by ELISA. Deposition of complement components C1, C3, C8 and C9 was observed in C6+/+ rats, but not in C6-/- animals. The histopathological changes, the liver weight increase and the elevation of the plasma pro-/anti-inflammatory TNF-alpha/IL-10 ratio were, on the other hand, more marked in C6-/- rats. Furthermore, ethanol enhanced the hepatic mRNA expression of the prostaglandin E receptors EP2R and EP4R exclusively in the C6-/- rats. Our results indicate that a deficient terminal complement pathway predisposes to tissue injury and promotes a pro-inflammatory cytokine response. This suggests that an intact complement system has a protective function in the development of alcoholic liver damage.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Alcoholic Liver Diseases resistanceIAGP 1600673 RGD 
Alcoholic Liver Diseases resistanceISOC6 (Rattus norvegicus)1600673; 1600673 RGD 

Objects Annotated

Genes (Rattus norvegicus)
C6  (complement C6)

Genes (Mus musculus)
C6  (complement component 6)

Genes (Homo sapiens)
C6  (complement C6)


Additional Information