RGD Reference Report - bcr-abl RNA in patients with chronic myelogenous leukemia. - Rat Genome Database

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bcr-abl RNA in patients with chronic myelogenous leukemia.

Authors: Shtivelman, E  Gale, RP  Dreazen, O  Berrebi, A  Zaizov, R  Kubonishi, I  Miyoshi, I  Canaani, E 
Citation: Shtivelman E, etal., Blood. 1987 Mar;69(3):971-3.
RGD ID: 1600510
Pubmed: PMID:3101769   (View Abstract at PubMed)

The major consequence of the formation of the Philadelphia (Ph1) chromosome characteristic of leukemia cells of patients with chronic myelogenous leukemia (CML) is fusion of c-abl and bcr genes. Using a sensitive RNase protection technique, we analyzed mRNA from a large number of CML patients. In most, we identified one or both species of bcr-abl chimeric transcripts. These two mRNAs vary in the specific bcr exon joined to abl exon II and are translated into slightly different proteins. The amounts of the fused mRNA within leukemia cells vary considerably between individuals and do not correlate with the phase of the disease.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
chronic myeloid leukemia susceptibilityIAGP 1600510DNA:gene fusionRGD 
chronic myeloid leukemia susceptibilityISOBCR (Homo sapiens)1600510DNA:gene fusionRGD 

Objects Annotated

Genes (Rattus norvegicus)
Bcr  (BCR activator of RhoGEF and GTPase)

Genes (Homo sapiens)
BCR  (BCR activator of RhoGEF and GTPase)


Additional Information