RGD Reference Report - Transgenic rats overexpressing the human MrgX3 gene show cataracts and an abnormal skin phenotype. - Rat Genome Database

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Transgenic rats overexpressing the human MrgX3 gene show cataracts and an abnormal skin phenotype.

Authors: Kaisho, Y  Watanabe, T  Nakata, M  Yano, T  Yasuhara, Y  Shimakawa, K  Mori, I  Sakura, Y  Terao, Y  Matsui, H  Taketomi, S 
Citation: Kaisho Y, etal., Biochem Biophys Res Commun. 2005 May 13;330(3):653-7.
RGD ID: 1600175
Pubmed: (View Article at PubMed) PMID:15809047
DOI: Full-text: DOI:10.1016/j.bbrc.2005.03.027

The human MrgX3 gene, belonging to the mrgs/SNSRs (mas related genes/sensory neuron specific receptors) family, was overexpressed in transgenic rats using the actin promoter. Two animal lines showed cataracts with liquification/degeneration and swelling of the lens fiber cells. The transient epidermal desquamation was observed in line with higher gene expression. Histopathology of the transgenic rats showed acanthosis and focal parakeratosis. In the epidermis, there was an increase in cellular keratin 14, keratin 10, and loricrin, as well as PGP 9.5 in innervating nerve fibers. These phenotypes accompanied an increase in the number of proliferating cells. These results suggest that overexpression of the human MrgX3 gene causes a disturbance of the normal cell-differentiation process.



Disease Annotations    
Parakeratosis  (IEP,ISO)

Objects Annotated

Genes (Rattus norvegicus)
Krt14  (keratin 14)

Genes (Mus musculus)
Krt14  (keratin 14)

Genes (Homo sapiens)
KRT14  (keratin 14)


Additional Information