RGD Reference Report - Thyroxine-binding globulin and thyroxine-binding prealbumin in hypothyroid and hyperthyroid developing rats. - Rat Genome Database

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Thyroxine-binding globulin and thyroxine-binding prealbumin in hypothyroid and hyperthyroid developing rats.

Authors: Savu, L  Vranckx, R  Maya, M  Gripois, D  Blouquit, MF  Nunez, EA 
Citation: Savu L, etal., Biochim Biophys Acta. 1989 Sep 15;992(3):379-84.
RGD ID: 1600139
Pubmed: PMID:2505856   (View Abstract at PubMed)

We present evidence based on equilibrium and non-equilibrium binding studies, as well as on immunological techniques, that of the two rat specific thyroid-hormone-binding proteins, i.e., thyroxine-binding globulin (TBG) and thyroxine-binding prealbumin (TBPA), TBG but not TBPA is regulated by the thyroid hormones (TH). Hypothyroidism, induced from the day of birth by daily treatment with propylthiouracil (PTU-rats), leads to dramatic and sustained increases of the TH-binding abilities of the sera measured at equilibrium, whereas hyperthyroidism, induced by treatment with thyroxine (T4-rats), leads to the decrease of these abilities. Polyacrylamide gel electrophoresis and isoelectrofocalisation of radioiodinated T4-labelled sera, together with immunoassay of TBPA, demonstrate that both effects are due to TBG, the levels of which rise in PTU-rats and decline in T4-rats, while TBPA levels do not respond to either depletion or excess of the thyroid hormones. TBG rather than TBPA appears as the key thyroid-hormone-binding protein of the rat, inasmuch as it alone expresses a regulatory function of the thyroid hormones at protein synthesis level.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
hyperthyroidism  ISOSerpina7 (Rattus norvegicus)1600139; 1600139protein:decreased expression:serum (rat)RGD 
hyperthyroidism  IEP 1600139protein:decreased expression:serum (rat)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Serpina7  (serpin family A member 7)

Genes (Mus musculus)
Serpina7  (serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7)

Genes (Homo sapiens)
SERPINA7  (serpin family A member 7)


Additional Information