RGD Reference Report - Hepatic and skeletal muscle glycogen metabolism in rats with short-term cholestasis. - Rat Genome Database

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Hepatic and skeletal muscle glycogen metabolism in rats with short-term cholestasis.

Authors: Lang, C  Schafer, M  Varga, L  Zimmermann, A  Krahenbuhl, S  Krahenbuhl, L 
Citation: Lang C, etal., J Hepatol. 2002 Jan;36(1):22-9.
RGD ID: 1599990
Pubmed: PMID:11804660   (View Abstract at PubMed)

Background/Aims: To study the effect of short-term cholestasis on glycogen metabolism.Methods: Rats were bile duct ligated (BDL) for 4 or 8 days and compared to sham-operated control rats pair-fed to BDL (pair-fed CON) or fed ad libitum (ad libitum-fed CON).Results: Four days after surgery, the hepatic glycogen content was 21.6+/-7.6 mg/g in BDL, 21.2+/-8.5 mg/g in pair-fed CON and 72.9+/-7.7 mg/g in ad libitum-fed CON, respectively. Eight days after surgery, the hepatic glycogen content was reduced in BDL as compared to pair-fed (31.2+/-8.9 vs. 59.1+/-5.4 mg/g) or ad libitum-fed CON (58.3+/-4.7 mg/g). Similar findings were obtained with the glycogen content expressed per ml hepatocytes or per liver. Histological analysis of BDL livers showed that most hepatocytes were affected. As compared to CON, activities and mRNA levels of glycogen synthase and phosphorylase were reduced in BDL, whereas plasma glucagon and endotoxin levels were increased at both time points. In contrast to liver, skeletal muscle glycogen metabolism remained unaffected.Conclusions: While reduced intake of food explains the decrease in the hepatic glycogen stores in BDL and pair-fed CON 4 days after surgery, reduced glycogen synthesis, possibly related to endotoxinemia, is the most probable cause of the decrease in the hepatic glycogen content in BDL 8 days after surgery.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
PYGMHumancholestasis  ISOPygm (Rattus norvegicus)mRNA:decreased expression:liverRGD 
PygmRatcholestasis  IDA mRNA:decreased expression:liverRGD 
PygmMousecholestasis  ISOPygm (Rattus norvegicus)mRNA:decreased expression:liverRGD 

Objects Annotated

Genes (Rattus norvegicus)
Pygm  (glycogen phosphorylase, muscle associated)

Genes (Mus musculus)
Pygm  (muscle glycogen phosphorylase)

Genes (Homo sapiens)
PYGM  (glycogen phosphorylase, muscle associated)


Additional Information