RGD Reference Report - PTHrP and PTH/PTHrP receptor 1 expression in odontogenic cells of normal and HHM model rat incisors. - Rat Genome Database

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PTHrP and PTH/PTHrP receptor 1 expression in odontogenic cells of normal and HHM model rat incisors.

Authors: Kato, A  Suzuki, M  Karasawa, Y  Sugimoto, T  Doi, K 
Citation: Kato A, etal., Toxicol Pathol. 2005;33(4):456-64.
RGD ID: 1599980
Pubmed: PMID:16036863   (View Abstract at PubMed)
DOI: DOI:10.1080/01926230590959604   (Journal Full-text)

Parathyroid hormone related peptide (PTHrP) was discovered as a causative factor of humoral hypercalcemia of malignancy (HHM). We examined PTHrP and its receptor (PTHR1) expression patterns in odontogenic cells in normal and HHM model rat incisors. Nontreated nude rats serving as the normal control and HHM model rats produced by implantation of PTHrP-expressing tumor (LC-6) cells were prepared. HHM rats fractured its incisor, and histopathologically, restrict population of odontoblasts showed findings classified as "shortening of high columnar odontoblasts" and "dentin niche." The incisors were immunostained against PTHrP and PTHR1. In normal rats, PTHrP and PTHR1 colocalized in ameloblasts, cementoblasts, and odontoblastic cells from mesenchymal cells to columnar odontoblasts. In high columnar odontoblasts, PTHrP solely expressed. In the HHM animals, although the expression patterns were identical to those of the normal rats in normal area, the shortened high columnar odontoblasts maintained PTHR1 expression and dentin niche comprising odontoblastic cells expressed both proteins. In the HHM model, the protein expression patterns changed in the odontoblastic cells with histological anomalies, and thus direct relations between the anomalies and PTHrP/PTHR1 axis are suggested.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
hypercalcemia  ISOPth1r (Rattus norvegicus)1599980; 1599980protein:increased expression:odontoblast and associated with neoplasms RGD 
hypercalcemia  IDA 1599980protein:increased expression:odontoblast and associated with neoplasms RGD 

Objects Annotated

Genes (Rattus norvegicus)
Pth1r  (parathyroid hormone 1 receptor)

Genes (Mus musculus)
Pth1r  (parathyroid hormone 1 receptor)

Genes (Homo sapiens)
PTH1R  (parathyroid hormone 1 receptor)


Additional Information