RGD Reference Report - Entry of herpes simplex virus type 1 into primary sensory neurons in vitro is mediated by Nectin-1/HveC. - Rat Genome Database

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Entry of herpes simplex virus type 1 into primary sensory neurons in vitro is mediated by Nectin-1/HveC.

Authors: Richart, SM  Simpson, SA  Krummenacher, C  Whitbeck, JC  Pizer, LI  Cohen, GH  Eisenberg, RJ  Wilcox, CL 
Citation: Richart SM, etal., J Virol. 2003 Mar;77(5):3307-11.
RGD ID: 1599797
Pubmed: (View Article at PubMed) PMID:12584355

Primary cultures of rat and mouse sensory neurons were used to study the entry of herpes simplex virus type 1 (HSV-1). Soluble, truncated nectin-1 but not HveA prevented viral entry. Antibodies against nectin-1 also blocked infection of rat neurons. These results indicate that nectin-1 is the primary receptor for HSV-1 infection of sensory neurons.

Annotation

Gene Ontology Annotations    

Biological Process

Molecular Function

Objects Annotated

Genes (Rattus norvegicus)
Nectin1  (nectin cell adhesion molecule 1)


Additional Information