RGD Reference Report - [Disorders of the processes of protein biosynthesis and a decrease in the content of cytochromes P-450 and b5 in the microsomal fraction of rat kidney in the dynamics of development of acute pyelonephritis] - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

[Disorders of the processes of protein biosynthesis and a decrease in the content of cytochromes P-450 and b5 in the microsomal fraction of rat kidney in the dynamics of development of acute pyelonephritis]

Authors: Karimov, KHIA  Akhmedov, RN  Inoiatova, FKH 
Citation: Karimov KhIa, etal., Ukr Biokhim Zh. 1998 Jul-Aug;70(4):139-42.
RGD ID: 1599663
Pubmed: PMID:9848217   (View Abstract at PubMed)

Noticeable decrease in microsomal protein level MOS terminal component--cytochrome P-450 and MOS median link--cytochrome b5 contents in microsomal fraction implicated in renal pathologic process was established in development of acute unilateral pyelonephritis. These findings reduction expression directly depended on severity and pathologic process development degree. One of the main causes led to reduction in cytochromes P-450 and b5 level and inhibition proteins biosynthesis may be influence of toxic products which are generated in substance exchange involved in prevalence of catabolic processes in injured kidney and intensification in endogenous intoxication syndrome on renal structures. Implication of many other factors effecting decrease in microsomal hemoproteins and protein levels in the damaged kidney in above pathology showed necessity to perform further investigations in the field given.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CYB5AHumanpyelonephritis  ISOCyb5a (Rattus norvegicus) RGD 
Cyb5aRatpyelonephritis  IEP  RGD 
Cyb5aMousepyelonephritis  ISOCyb5a (Rattus norvegicus) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cyb5a  (cytochrome b5 type A)

Genes (Mus musculus)
Cyb5a  (cytochrome b5 type A (microsomal))

Genes (Homo sapiens)
CYB5A  (cytochrome b5 type A)


Additional Information