RGD Reference Report - Enzymes of the pathway of purine synthesis in the rat mammary gland. Changes in the lactation cycle and the effects of diabetes. - Rat Genome Database

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Enzymes of the pathway of purine synthesis in the rat mammary gland. Changes in the lactation cycle and the effects of diabetes.

Authors: Beardsley, S  Kunjara, S  Greenbaum, AL 
Citation: Beardsley S, etal., Biochem J. 1988 Mar 1;250(2):395-9.
RGD ID: 1599204
Pubmed: PMID:2451510   (View Abstract at PubMed)
PMCID: PMC1148869   (View Article at PubMed Central)

Measurements were made of the activities of the enzymes of the 'de novo' and salvage pathways of purine synthesis [phosphoribosyl pyrophosphate amidotransferase (EC 2.4.2.14), adenine phosphoribosyltransferase (EC 2.4.2.7) and hypoxanthine phosphoribosyltranferase (EC 2.4.2.8)] at different stages of the lactation cycle, and the effects of diabetes on the activity of these enzymes in lactation were studied. A distinctive pattern of enzyme change was observed, in which the 'de novo' pathway enzyme phosphoribosyl pyrophosphate amidotransferase increased sharply between days 10 and 14 of pregnancy, and then remained sensibly constant until the height of lactation, whereas the enzymes of the salvage pathway increased later in pregnancy and continued to rise during lactation. Diabetes severely depressed the activity of the enzymes of the salvage pathway, but appeared to be without effect on the 'de novo' pathway enzyme. These results are discussed in relation to the provision of purine precursors from tissues outside the mammary gland.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
APRTHumanExperimental Diabetes Mellitus  ISOAprt (Rattus norvegicus)protein:decreased activity:mammary gland (rat)RGD 
AprtRatExperimental Diabetes Mellitus  IEP protein:decreased activity:mammary gland (rat)RGD 
AprtMouseExperimental Diabetes Mellitus  ISOAprt (Rattus norvegicus)protein:decreased activity:mammary gland (rat)RGD 

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
AprtRatlactation  IDA  RGD 
PpatRatlactation  IEP  RGD 
PpatRatmaternal process involved in female pregnancy  IEP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Aprt  (adenine phosphoribosyl transferase)
Ppat  (phosphoribosyl pyrophosphate amidotransferase)

Genes (Mus musculus)
Aprt  (adenine phosphoribosyl transferase)

Genes (Homo sapiens)
APRT  (adenine phosphoribosyltransferase)


Additional Information