RGD Reference Report - Congenic Strains Confirm Aerobic Running Capacity Quantitative Trait Loci on Rat Chromosome 16 and Identify Possible Intermediate Phenotypes. - Rat Genome Database

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Congenic Strains Confirm Aerobic Running Capacity Quantitative Trait Loci on Rat Chromosome 16 and Identify Possible Intermediate Phenotypes.

Authors: Ways, JA  Smith, BM  Barbato, JC  Ramdath, RS  Pettee, KM  Deraedt, SJ  Allison, DC  Koch, LG  Lee, SJ  Cicila, GT 
Citation: Ways JA, etal., Physiol Genomics. 2006 Dec 19;.
RGD ID: 1598978
Pubmed: PMID:17179209   (View Abstract at PubMed)
DOI: DOI:10.1152/physiolgenomics.00027.2006   (Journal Full-text)

We previously identified two inbred rat strains divergent for treadmill aerobic running capacity (ARC), the low performing Copenhagen (COP) and the high performing DA rats, and used an F2(COPxDA) population to identify ARC quantitative trait loci (QTLs) on rat chromosome 16 (RNO16) and the proximal portion of rat chromosome 3 (RNO3). Two congenic rat strains were bred to further investigate these ARC QTLs by introgressing RNO16 and the proximal portion of RNO3 from DA rats into the genetic background of COP rats and were named COP.DA(chr 16) and COP.DA(chr 3), respectively. COP.DA(chr 16) rats had significantly greater ARC compared to COP rats (696.7+/-38.2 m vs. 571.9+/-27.5 m, P=0.03). COP.DA(chr 3) rats had increased, although not significant, ARC compared to COP rats (643.6+/-40.9 m vs. 571.9+/-27.5 m). COP.DA(chr 16) rats had significantly greater subcutaneous abdominal fat, as well as decreased fasting triglyceride levels, compared to COP rats (P<0.05), indicating that genes responsible for strain differences in fat metabolism are also located on RNO16. While this colocalization of QTLs may be coincidental, it is also possible that these differences in energy balance may be associated with the superior running performance of COP.DA(chr 16) consomic rats. Key words: Treadmill endurance test, consomic, subcutaneous abdominal fat, abdominal fat, triglycerides.



Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
COP.DA-(D3Rat233-D3Mgh14)/McoRatdecreased body weight  IAGP compared to COP/OlaHsdRGD 
DA/OlaHsdRatdecreased body weight  IAGP compared to COP/OlaHsdRGD 
COP.DA-(D16Rat12-D16Rat90)/McoRatdecreased circulating triglyceride level  IAGP compared to COP/OlaHsdRGD 
COP.DA-(D3Rat233-D3Mgh14)/McoRatdecreased kidney weight  IAGP compared to COP/OlaHsdRGD 
DA/OlaHsdRatdecreased liver weight  IAGP compared to COP/OlaHsdRGD 
COP.DA-(D3Rat233-D3Mgh14)/McoRatdecreased pancreas weight  IAGP compared to COP/OlaHsdRGD 
COP.DA-(D16Rat12-D16Rat90)/McoRatincreased abdominal fat pad weight  IAGP compared to COP/OlaHsdRGD 
DA/OlaHsdRatincreased abdominal fat pad weight  IAGP compared to COP/OlaHsdRGD 
Arunc4Ratincreased aerobic running capacity  IAGP  RGD 
Arunc5Ratincreased aerobic running capacity  IAGP  RGD 
COP.DA-(D16Rat12-D16Rat90)/McoRatincreased aerobic running capacity  IAGP compared to COP/OlaHsdRGD 
DA/OlaHsdRatincreased aerobic running capacity  IAGP compared to COP/OlaHsdRGD 
DA/OlaHsdRatincreased heart left ventricle weight  IAGP compared to COP/OlaHsdRGD 
DA/OlaHsdRatincreased heart weight  IAGP compared to COP/OlaHsdRGD 
DA/OlaHsdRatincreased retroperitoneal fat pad weight  IAGP compared to COP/OlaHsdRGD 
COP.DA-(D16Rat12-D16Rat90)/McoRatincreased subcutaneous adipose tissue amount  IAGP compared to COP/OlaHsdRGD 
COP.DA-(D3Rat233-D3Mgh14)/McoRatincreased subcutaneous adipose tissue amount  IAGP compared to COP/OlaHsdRGD 
DA/OlaHsdRatincreased subcutaneous adipose tissue amount  IAGP compared to COP/OlaHsdRGD 

Objects Annotated

QTLs
Arunc4  (Aerobic running capacity QTL 4)
Arunc5  (Aerobic running capacity QTL 5)

Objects referenced in this article
Strain COP-Chr 16DA/McoRrrc null Rattus norvegicus

Additional Information