RGD Reference Report - Congenic Strains Confirm Aerobic Running Capacity Quantitative Trait Loci on Rat Chromosome 16 and Identify Possible Intermediate Phenotypes. - Rat Genome Database

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Congenic Strains Confirm Aerobic Running Capacity Quantitative Trait Loci on Rat Chromosome 16 and Identify Possible Intermediate Phenotypes.

Authors: Ways, JA  Smith, BM  Barbato, JC  Ramdath, RS  Pettee, KM  Deraedt, SJ  Allison, DC  Koch, LG  Lee, SJ  Cicila, GT 
Citation: Ways JA, etal., Physiol Genomics. 2006 Dec 19;.
RGD ID: 1598978
Pubmed: (View Article at PubMed) PMID:17179209
DOI: Full-text: DOI:10.1152/physiolgenomics.00027.2006

We previously identified two inbred rat strains divergent for treadmill aerobic running capacity (ARC), the low performing Copenhagen (COP) and the high performing DA rats, and used an F2(COPxDA) population to identify ARC quantitative trait loci (QTLs) on rat chromosome 16 (RNO16) and the proximal portion of rat chromosome 3 (RNO3). Two congenic rat strains were bred to further investigate these ARC QTLs by introgressing RNO16 and the proximal portion of RNO3 from DA rats into the genetic background of COP rats and were named COP.DA(chr 16) and COP.DA(chr 3), respectively. COP.DA(chr 16) rats had significantly greater ARC compared to COP rats (696.7+/-38.2 m vs. 571.9+/-27.5 m, P=0.03). COP.DA(chr 3) rats had increased, although not significant, ARC compared to COP rats (643.6+/-40.9 m vs. 571.9+/-27.5 m). COP.DA(chr 16) rats had significantly greater subcutaneous abdominal fat, as well as decreased fasting triglyceride levels, compared to COP rats (P<0.05), indicating that genes responsible for strain differences in fat metabolism are also located on RNO16. While this colocalization of QTLs may be coincidental, it is also possible that these differences in energy balance may be associated with the superior running performance of COP.DA(chr 16) consomic rats. Key words: Treadmill endurance test, consomic, subcutaneous abdominal fat, abdominal fat, triglycerides.




Phenotype Values via PhenoMiner     Click to see Annotation Detail View
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Strains with Phenominer Data Strains with phenominer dataStrains with phenominer data
COP/OlaHsd DA/OlaHsd COP.DA-(D16Rat12-D16Rat90)/Mco
COP.DA-(D3Rat233-D3Mgh14)/Mco

Objects Annotated

QTLs
Arunc4  (Aerobic running capacity QTL 4)
Arunc5  (Aerobic running capacity QTL 5)

Objects referenced in this article
Strain COP-Chr 16DA/McoRrrc null Rattus norvegicus

Additional Information