RGD Reference Report - Dysregulated expression of ebaf, a novel molecular defect in the endometria of patients with infertility. - Rat Genome Database

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Dysregulated expression of ebaf, a novel molecular defect in the endometria of patients with infertility.

Authors: Tabibzadeh, S  Mason, JM  Shea, W  Cai, Y  Murray, MJ  Lessey, B 
Citation: Tabibzadeh S, etal., J Clin Endocrinol Metab. 2000 Jul;85(7):2526-36.
RGD ID: 1598793
Pubmed: PMID:10902804   (View Abstract at PubMed)
DOI: DOI:10.1210/jcem.85.7.6674   (Journal Full-text)

We recently described the expression of ebaf, a novel member of the transforming growth factor-beta superfamily in human endometrium. ebaf messenger ribonucleic acid was expressed in late secretory and menstrual endometria. Here, we show that ebaf is secreted as 42-, 34-, 28-, and 14-kDa proteins into the conditioned medium of transfected cells, endometrial fluid, and serum. The amount of secreted proteins was markedly reduced during the implantation window in the endometria and sera of normal fertile subjects. The expression of ebaf was dysregulated in the endometria of a subset of women with infertility during the receptive phase of the menstrual cycle. Abundant secreted protein was present in the endometria of these women during the implantation window. During the critical period of endometrial receptivity, ebaf protein was more abundant in patients with endometriosis who did not conceive than in patients who became pregnant. These findings show that ebaf is a secreted product and is released into body fluids. Some types of infertility are associated with dysregulated expression of ebaf in human endometrium, suggesting that a molecular defect in uterine receptivity may be identified using such a marker protein.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
LEFTY2HumanFemale Infertility  IEP  RGD 
Lefty2RatFemale Infertility  ISOLEFTY2 (Homo sapiens) RGD 
Lefty2MouseFemale Infertility  ISOLEFTY2 (Homo sapiens) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Lefty2  (Left-right determination factor 2)

Genes (Mus musculus)
Lefty2  (left-right determination factor 2)

Genes (Homo sapiens)
LEFTY2  (left-right determination factor 2)


Additional Information