RGD Reference Report - Evidence for a female-specific effect of a chromosome 4 locus on anxiety-related behaviors and ethanol drinking in rats. - Rat Genome Database

RGD Reference Report - Evidence for a female-specific effect of a chromosome 4 locus on anxiety-related behaviors and ethanol drinking in rats. - Rat Genome Database

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Evidence for a female-specific effect of a chromosome 4 locus on anxiety-related behaviors and ethanol drinking in rats.
Authors:	Vendruscolo, LF Terenina-Rigaldie, E Raba, F Ramos, A Takahashi, RN Mormede, P
Citation:	Vendruscolo LF, etal., Genes Brain Behav. 2006 Aug;5(6):441-50.
RGD ID:	1598390
Pubmed:	PMID:16923148 (View Abstract at PubMed)
DOI:	DOI:10.1111/j.1601-183X.2005.00177.x (Journal Full-text)
Previous studies using the inbred rat strains Lewis (LEW) and spontaneously hypertensive rats (SHR) led to the mapping of two quantitative trait loci, named Ofil1 (on chromosome 4 of the rat) and Ofil2 (on chromosome 7), for open-field inner locomotion, a behavioral index of anxiety. Studies using other strains showed that the region next to Ofil1 influences measures of not only anxiety but also ethanol consumption. In view of the high prevalence of psychiatric disorders such as anxiety and alcoholism, as well as the comorbidity between them, the present study was designed to better characterize the contribution of these two loci to complex emotional and consummatory responses. Rats deriving from an F2 intercross between the LEW and the SHR strains were selected according to their genotype at markers flanking the loci Ofil1 and Ofil2 and bred to obtain lines of rats homozygous LEW/LEW or SHR/SHR for each of the two loci, thus generating four genotypic combinations. These selected animals as well as purebred LEW and SHR rats of both sexes were submitted to a battery of tests including measures of locomotor activity, anxiety, sweet and bitter taste reinforcement and ethanol intake. Lewis rats displayed more anxiety-like behavior and less ethanol intake than SHR rats. Ofil1 (on chromosome 4) affected both the activity in the center of the open field and ethanol drinking in females only. These results suggest that Ofil1 contains either linked genes with independent influences on anxiety-related responses and ethanol drinking or a pleiotropic gene with simultaneous effects on both traits.

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Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Notes	Source	Original Reference(s)
LEW/NIcoCrlf	Rat	alcohol use disorder	resistance	IAGP			RGD

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

Object Symbol	Species	Term	Qualifier	Evidence	With	Notes	Source	Original Reference(s)
SHR/NIcoCrlf	Rat	alcohol preference	sexual_dimorphism	IAGP		females compared to LEW/NlcoCrlf females at higher alcohol concentrations	RGD
SHR/NIcoCrlf	Rat	alcohol preference		IAGP		compared to LEW/NlcoCrlf strain at lower alcohol concentrations	RGD
LEW/NIcoCrlf	Rat	decreased alcohol consumption		IAGP			RGD
SHR/NIcoCrlf	Rat	decreased anxiety-related response		IAGP		compared to LEW/NlcoCrlf strain	RGD
SHR/NIcoCrlf	Rat	hyperactivity	sexual_dimorphism	IAGP		females compared to LEW/NIcoCrlf females	RGD
LEW/NIcoCrlf	Rat	low sweet preference		IAGP		compared to SHR/NIcoCrlf strain	RGD

Objects Annotated

Strains

LEW/NIcoCrlf (NA)

SHR/NIcoCrlf (NA)

Objects referenced in this article

QTL	Anxrr16	Anxiety related response QTL 16	Rattus norvegicus
QTL	Anxrr17	Anxiety related response QTL 17	Rattus norvegicus

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