RGD Reference Report - HLA-DMA and HLA-DMB genotyping in patients with rheumatic diseases. - Rat Genome Database

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HLA-DMA and HLA-DMB genotyping in patients with rheumatic diseases.

Authors: Yen, JH  Tsai, WC  Tsai, JJ  Chen, CJ  Lin, CH  Ou, TT  Wu, CC  Liu, HW 
Citation: Yen JH, etal., Kaohsiung J Med Sci. 1999 May;15(5):263-7.
RGD ID: 1582700
Pubmed: (View Article at PubMed) PMID:10375868

To investigate the correlation of HLA-DMA and DMB alleles to some rheumatic diseases, HLA-DMA and DMB genes were detected in 11 patients with juvenile rheumatoid arthritis (JRA), 22 patients with psoriatic arthritis, 26 patients with Behcet's disease, 62 patients with ankylosing spondylitis (AS), and 138 unrelated healthy controls. There was no significant difference in phenotypic frequencies of HLA-DMA and DMB alleles between controls and patients with these rheumatic diseases. HLA-DMA and DMB genes are not related to the susceptibility of JRA, psoriatic arthritis, Behcet's disease, and AS.

Annotation

Disease Annotations    
Behcet's disease  (IAGP,ISO)

Objects Annotated

Genes (Rattus norvegicus)
RT1-DMa  (RT1 class II, locus DMa)
RT1-DMb  (RT1 class II, locus DMb)

Genes (Mus musculus)
H2-DMa  (histocompatibility 2, class II, locus DMa)
H2-DMb2  (histocompatibility 2, class II, locus Mb2)

Genes (Homo sapiens)
HLA-DMA  (major histocompatibility complex, class II, DM alpha)
HLA-DMB  (major histocompatibility complex, class II, DM beta)


Additional Information