RGD Reference Report - Expression of Musashi-1 in the rat stomach and changes during mucosal injury and restitution. - Rat Genome Database

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Expression of Musashi-1 in the rat stomach and changes during mucosal injury and restitution.

Authors: Nagata, H  Akiba, Y  Suzuki, H  Okano, H  Hibi, T 
Citation: Nagata H, etal., FEBS Lett. 2006 Jan 9;580(1):27-33. Epub 2005 Dec 6.
RGD ID: 1582662
Pubmed: PMID:16360154   (View Abstract at PubMed)
DOI: DOI:10.1016/j.febslet.2005.11.041   (Journal Full-text)

Musashi-1 is involved in maintenance of neural stem cells. In the rat stomach, we found some cells in the luminal compartment of the mucosa that stained positively for Musashi-1. These cells were distinct from other cells of epithelial lineage, except for parietal cells, and coexpressed HES5. The Musashi-1-positive cells exfoliated after damage, while Musashi-1 expression in neck cells were upregulated, and proliferating cells diminished before reappearing and increasing in number thereafter. We conclude that a subpopulation of parietal cells acts as a source of Musashi-1, which contributes to rapid re-epithelization by restoration of stem cells and regulation of cell differentiation.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
epithelial cell differentiation  IEP 1582662 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Msi1  (musashi RNA-binding protein 1)


Additional Information